RT Journal Article
T1 Immune Microenvironment in Colorectal Cancer: A New Hallmark to Change Old Paradigms
A1 Cruz-Merino, Luis de la
A1 Henao Carrasco, Fernando
A1 Vicente Baz, David
A1 Nogales Fernández, Esteban
A1 Reina Zoilo, Juan José
A1 Codes Manuel de Villena, Manuel
A1 Grande Pulido, Enrique
K1 Antígenos CD80
K1 Antineoplásicos
K1 Antígeno CTLA-4
K1 Neoplasias Colorrectales
K1 Pronóstico
K1 Linfocitos T Reguladores
AB Impact of immune microenvironment in prognosis of solid tumors has been extensively studied in the last few years. Specifically in colorectal carcinoma, increased knowledge of the immune events around these tumors and their relation with clinical outcomes have led to consider immune microenvironment as one of the most important prognostic factors in this disease. In this review we will summarize and update the current knowledge with respect to this intriguing and complex new hallmark of cancer, paying special attention to infiltration by T-infiltrating lymphocytes and their subtypes in colorectal cancer, as well as its eventual clinical translation in terms of long-term prognosis. Finally, we suggest some possible investigational approaches based on combinatorial strategies to trigger and boost immune reaction against tumor cells.
PB Hindawi Publishing Corporation
SN 1740-2522
YR 2011
FD 2011
LK http://hdl.handle.net/10668/1098
UL http://hdl.handle.net/10668/1098
LA en
NO Cruz-Merino L de la, Henao Carrasco F, Vicente Baz D, Nogales Fernández E, Reina Zoilo JJ, Codes Manuel de Villena M, et al. Immune microenvironment in colorectal cancer: a new hallmark to change old paradigms. Clin. Dev. Immunol.; 2011:174149
NO Journal Article; Review;
DS RISalud
RD Apr 5, 2025