RT Journal Article
T1 Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition.
A1 Kliemann, Nathalie
A1 Murphy, Neil
A1 Viallon, Vivian
A1 Freisling, Heinz
A1 Tsilidis, Konstantinos K
A1 Rinaldi, Sabina
A1 Mancini, Francesca R
A1 Fagherazzi, Guy
A1 Boutron-Ruault, Marie-Christine
A1 Boeing, Heiner
A1 Schulze, Matthias B
A1 Masala, Giovanna
A1 Krogh, Vittorio
A1 Sacerdote, Carlotta
A1 de Magistris, Maria S
A1 Bueno-de-Mesquita, Bas
A1 Weiderpass, Elisabete
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Jakszyn, Paula
A1 Redondo-Sanchez, Daniel
A1 Amiano, Pilar
A1 Chirlaque, Maria-Dolores
A1 Gurrea, Aurelio B
A1 Ericson, Ulrica
A1 Drake, Isabel
A1 Nøst, Therese H
A1 Aune, Dagfinn
A1 May, Anne M
A1 Tjønneland, Anne
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Tumino, Rosario
A1 Quiros, Jose R
A1 Trichopoulou, Antonia
A1 Karakatsani, Anna
A1 La Vecchia, Carlo
A1 Nilsson, Lena M
A1 Riboli, Elio
A1 Huybrechts, Inge
A1 Gunter, Marc J
K1 basal metabolic rate
K1 cancer
K1 metabolic disorder
K1 obesity
AB Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD ]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD : 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD : 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD : 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD : 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD : 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD : 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
PB John Wiley & Sons, Inc.
YR 2019
FD 2019-10-07
LK http://hdl.handle.net/10668/15333
UL http://hdl.handle.net/10668/15333
LA en
NO Kliemann N, Murphy N, Viallon V, Freisling H, Tsilidis KK, Rinaldi S, et al. Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2020 Aug 1;147(3):648-661.
DS RISalud
RD Apr 8, 2025