%0 Journal Article
%A Kliemann, Nathalie
%A Murphy, Neil
%A Viallon, Vivian
%A Freisling, Heinz
%A Tsilidis, Konstantinos K
%A Rinaldi, Sabina
%A Mancini, Francesca R
%A Fagherazzi, Guy
%A Boutron-Ruault, Marie-Christine
%A Boeing, Heiner
%A Schulze, Matthias B
%A Masala, Giovanna
%A Krogh, Vittorio
%A Sacerdote, Carlotta
%A de Magistris, Maria S
%A Bueno-de-Mesquita, Bas
%A Weiderpass, Elisabete
%A Kühn, Tilman
%A Kaaks, Rudolf
%A Jakszyn, Paula
%A Redondo-Sanchez, Daniel
%A Amiano, Pilar
%A Chirlaque, Maria-Dolores
%A Gurrea, Aurelio B
%A Ericson, Ulrica
%A Drake, Isabel
%A Nøst, Therese H
%A Aune, Dagfinn
%A May, Anne M
%A Tjønneland, Anne
%A Dahm, Christina C
%A Overvad, Kim
%A Tumino, Rosario
%A Quiros, Jose R
%A Trichopoulou, Antonia
%A Karakatsani, Anna
%A La Vecchia, Carlo
%A Nilsson, Lena M
%A Riboli, Elio
%A Huybrechts, Inge
%A Gunter, Marc J
%T Predicted basal metabolic rate and cancer risk in the European Prospective Investigation into Cancer and Nutrition.
%D 2019
%U http://hdl.handle.net/10668/15333
%X Emerging evidence suggests that a metabolic profile associated with obesity may be a more relevant risk factor for some cancers than adiposity per se. Basal metabolic rate (BMR) is an indicator of overall body metabolism and may be a proxy for the impact of a specific metabolic profile on cancer risk. Therefore, we investigated the association of predicted BMR with incidence of 13 obesity-related cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). BMR at baseline was calculated using the WHO/FAO/UNU equations and the relationships between BMR and cancer risk were investigated using multivariable Cox proportional hazards regression models. A total of 141,295 men and 317,613 women, with a mean follow-up of 14 years were included in the analysis. Overall, higher BMR was associated with a greater risk for most cancers that have been linked with obesity. However, among normal weight participants, higher BMR was associated with elevated risks of esophageal adenocarcinoma (hazard ratio per 1-standard deviation change in BMR [HR1-SD ]: 2.46; 95% CI 1.20; 5.03) and distal colon cancer (HR1-SD : 1.33; 95% CI 1.001; 1.77) among men and with proximal colon (HR1-SD : 1.16; 95% CI 1.01; 1.35), pancreatic (HR1-SD : 1.37; 95% CI 1.13; 1.66), thyroid (HR1-SD : 1.65; 95% CI 1.33; 2.05), postmenopausal breast (HR1-SD : 1.17; 95% CI 1.11; 1.22) and endometrial (HR1-SD : 1.20; 95% CI 1.03; 1.40) cancers in women. These results indicate that higher BMR may be an indicator of a metabolic phenotype associated with risk of certain cancer types, and may be a useful predictor of cancer risk independent of body fatness.
%K basal metabolic rate
%K cancer
%K metabolic disorder
%K obesity
%~