RT Journal Article
T1 Zebrafish Models for Human Skeletal Disorders
A1 Marí-Beffa, Manuel
A1 Mesa-Román, Ana B.
A1 Duran, Ivan
K1 Skeletal dysplasia
K1 Osteogenesis imperfecta
K1 Osteoporosis
K1 Skeletal ciliopathies
K1 Dwarfisms
K1 Dysostosis
K1 Osteopetrosis
K1 Zebrafish models
K1 Acrocefalosindactilia
K1 Dentinogénesis imperfecta
K1 Ciliopatías
K1 Disostosis
K1 Pez cebra
K1 Modelos animales
AB In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a reference list of recognized diseases in humans and their causal genes published to help clinician diagnosis and scientific research advances. Complementary to mammalian models, zebrafish has emerged as an interesting species to evaluate chemical treatments against these human skeletal disorders. Due to its versatility and the low cost of experiments, more than 80 models are currently available. In this article, we review the state-of-art of this "aquarium to bedside" approach describing the models according to the list provided by the Nosology Committee. With this, we intend to stimulate research in the appropriate direction to efficiently meet the actual needs of clinicians under the scope of the Nosology Committee.
PB Frontiers
YR 2021
FD 2021-08-05
LK http://hdl.handle.net/10668/4068
UL http://hdl.handle.net/10668/4068
LA en
NO Marí-Beffa M, Mesa-Román AB, Duran I. Zebrafish Models for Human Skeletal Disorders. Front Genet. 2021 Aug 5;12:675331
DS RISalud
RD Apr 7, 2025