TY  - JOUR
AU  - Barbier-Torres, Lucía
AU  - Iruzubieta, Paula
AU  - Fernández-Ramos, David
AU  - Delgado, Teresa C
AU  - Taibo, Daniel
AU  - Guitiérrez-de-Juan, Virginia
AU  - Varela-Rey, Marta
AU  - Azkargorta, Mikel
AU  - Navasa, Nicolas
AU  - Fernández-Tussy, Pablo
AU  - Zubiete-Franco, Imanol
AU  - Simon, Jorge
AU  - Lopitz-Otsoa, Fernando
AU  - Lachiondo-Ortega, Sofia
AU  - Crespo, Javier
AU  - Masson, Steven
AU  - McCain, Misti Vanette
AU  - Villa, Erica
AU  - Reeves, Helen
AU  - Elortza, Felix
AU  - Lucena, Maria Isabel
AU  - Hernández-Alvarez, Maria Isabel
AU  - Zorzano, Antonio
AU  - Andrade, Raúl J
AU  - Lu, Shelly C
AU  - Mato, José M
AU  - Anguita, Juan
AU  - Rincón, Mercedes
AU  - Martínez-Chantar, María Luz
PY  - 2017
DO  - 10.1038/s41467-017-01970-x
UR  - http://hdl.handle.net/10668/11900
T2  - Nature communications
AB  - Acetaminophen (APAP) is the active component of many medications used to treat pain and fever worldwide. Its overuse provokes liver injury and it is the second most common cause of liver failure. Mitochondrial dysfunction contributes to APAP-induced...
LA  - en
KW  - Acetaminophen
KW  - Adolescent
KW  - Adult
KW  - Animals
KW  - Chemical and Drug Induced Liver Injury
KW  - Disease Models, Animal
KW  - Drug Overdose
KW  - Electron Transport Complex I
KW  - Female
KW  - Gene Knockout Techniques
KW  - HSP40 Heat-Shock Proteins
KW  - Hepatocytes
KW  - Humans
KW  - Liver
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Middle Aged
KW  - Mitochondria, Liver
KW  - Mitochondrial Proteins
KW  - Molecular Chaperones
KW  - Primary Cell Culture
KW  - RNA, Small Interfering
KW  - Rotenone
KW  - Uncoupling Agents
KW  - Young Adult
TI  - The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
TY  - research article
VL  - 8
ER  -