RT Journal Article
T1 Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders.
A1 Writing Committee for the Attention-Deficit/Hyperactivity Disorder, 
A1 Autism Spectrum Disorder, 
A1 Bipolar Disorder, 
A1 Major Depressive Disorder, 
A1 Obsessive-Compulsive Disorder, 
A1 and Schizophrenia ENIGMA Working Groups, 
A1 Patel, Yash
A1 Parker, Nadine
A1 Shin, Jean
A1 Howard, Derek
A1 French, Leon
A1 Thomopoulos, Sophia I
A1 Pozzi, Elena
A1 Abe, Yoshinari
A1 Abé, Christoph
A1 Anticevic, Alan
A1 Alda, Martin
A1 Aleman, Andre
A1 Alloza, Clara
A1 Alonso-Lana, Silvia
A1 Ameis, Stephanie H
A1 Anagnostou, Evdokia
A1 McIntosh, Andrew A
A1 Arango, Celso
A1 Arnold, Paul D
A1 Asherson, Philip
A1 Assogna, Francesca
A1 Auzias, Guillaume
A1 Ayesa-Arriola, Rosa
A1 Bakker, Geor
A1 Banaj, Nerisa
A1 Banaschewski, Tobias
A1 Bandeira, Cibele E
A1 Baranov, Alexandr
A1 Bargalló, Núria
A1 Bau, Claiton H D
A1 Baumeister, Sarah
A1 Baune, Bernhard T
A1 Bellgrove, Mark A
A1 Benedetti, Francesco
A1 Bertolino, Alessandro
A1 Boedhoe, Premika S W
A1 Boks, Marco
A1 Bollettini, Irene
A1 Del Mar Bonnin, Caterina
A1 Borgers, Tiana
A1 Borgwardt, Stefan
A1 Brandeis, Daniel
A1 Brennan, Brian P
A1 Bruggemann, Jason M
A1 Bülow, Robin
A1 Busatto, Geraldo F
A1 Calderoni, Sara
A1 Calhoun, Vince D
A1 Calvo, Rosa
A1 Canales-Rodríguez, Erick J
A1 Cannon, Dara M
A1 Carr, Vaughan J
A1 Cascella, Nicola
A1 Cercignani, Mara
A1 Chaim-Avancini, Tiffany M
A1 Christakou, Anastasia
A1 Coghill, David
A1 Conzelmann, Annette
A1 Crespo-Facorro, Benedicto
A1 Cubillo, Ana I
A1 Cullen, Kathryn R
A1 Cupertino, Renata B
A1 Daly, Eileen
A1 Dannlowski, Udo
A1 Davey, Christopher G
A1 Denys, Damiaan
A1 Deruelle, Christine
A1 Di Giorgio, Annabella
A1 Dickie, Erin W
A1 Dima, Danai
A1 Dohm, Katharina
A1 Ehrlich, Stefan
A1 Ely, Benjamin A
A1 Erwin-Grabner, Tracy
A1 Ethofer, Thomas
A1 Fair, Damien A
A1 Fallgatter, Andreas J
A1 Faraone, Stephen V
A1 Fatjó-Vilas, Mar
A1 Fedor, Jennifer M
A1 Fitzgerald, Kate D
A1 Ford, Judith M
A1 Frodl, Thomas
A1 Fu, Cynthia H Y
A1 Fullerton, Janice M
A1 Gabel, Matt C
A1 Glahn, David C
A1 Roberts, Gloria
A1 Gogberashvili, Tinatin
A1 Goikolea, Jose M
A1 Gotlib, Ian H
A1 Goya-Maldonado, Roberto
A1 Grabe, Hans J
A1 Green, Melissa J
A1 Grevet, Eugenio H
A1 Groenewold, Nynke A
A1 Grotegerd, Dominik
A1 Gruber, Oliver
A1 Gruner, Patricia
A1 Guerrero-Pedraza, Amalia
A1 Gur, Raquel E
A1 Gur, Ruben C
A1 Haar, Shlomi
A1 Haarman, Bartholomeus C M
A1 Haavik, Jan
A1 Hahn, Tim
A1 Hajek, Tomas
A1 Harrison, Benjamin J
A1 Harrison, Neil A
A1 Hartman, Catharina A
A1 Whalley, Heather C
A1 Heslenfeld, Dirk J
A1 Hibar, Derrek P
A1 Hilland, Eva
A1 Hirano, Yoshiyuki
A1 Ho, Tiffany C
A1 Hoekstra, Pieter J
A1 Hoekstra, Liesbeth
A1 Hohmann, Sarah
A1 Hong, L E
A1 Höschl, Cyril
A1 Høvik, Marie F
A1 Howells, Fleur M
A1 Nenadic, Igor
A1 Jalbrzikowski, Maria
A1 James, Anthony C
A1 Janssen, Joost
A1 Jaspers-Fayer, Fern
A1 Xu, Jian
A1 Jonassen, Rune
A1 Karkashadze, Georgii
A1 King, Joseph A
A1 Kircher, Tilo
A1 Kirschner, Matthias
A1 Koch, Kathrin
A1 Kochunov, Peter
A1 Kohls, Gregor
A1 Konrad, Kerstin
A1 Krämer, Bernd
A1 Krug, Axel
A1 Kuntsi, Jonna
A1 Kwon, Jun Soo
A1 Landén, Mikael
A1 Landrø, Nils I
A1 Lazaro, Luisa
A1 Lebedeva, Irina S
A1 Leehr, Elisabeth J
A1 Lera-Miguel, Sara
A1 Lesch, Klaus-Peter
A1 Lochner, Christine
A1 Louza, Mario R
A1 Luna, Beatriz
A1 Lundervold, Astri J
A1 MacMaster, Frank P
A1 Maglanoc, Luigi A
A1 Malpas, Charles B
A1 Portella, Maria J
A1 Marsh, Rachel
A1 Martyn, Fiona M
A1 Mataix-Cols, David
A1 Mathalon, Daniel H
A1 McCarthy, Hazel
A1 McDonald, Colm
A1 McPhilemy, Genevieve
A1 Meinert, Susanne
A1 Menchón, José M
A1 Minuzzi, Luciano
A1 Mitchell, Philip B
A1 Moreno, Carmen
A1 Morgado, Pedro
A1 Muratori, Filippo
A1 Murphy, Clodagh M
A1 Murphy, Declan
A1 Mwangi, Benson
A1 Nabulsi, Leila
A1 Nakagawa, Akiko
A1 Nakamae, Takashi
A1 Namazova, Leyla
A1 Narayanaswamy, Janardhanan
A1 Jahanshad, Neda
A1 Nguyen, Danai D
A1 Nicolau, Rosa
A1 O'Gorman Tuura, Ruth L
A1 O'Hearn, Kirsten
A1 Oosterlaan, Jaap
A1 Opel, Nils
A1 Ophoff, Roel A
A1 Oranje, Bob
A1 García de la Foz, Victor Ortiz
A1 Overs, Bronwyn J
A1 Paloyelis, Yannis
A1 Pantelis, Christos
A1 Parellada, Mara
A1 Pauli, Paul
A1 Picó-Pérez, Maria
A1 Picon, Felipe A
A1 Piras, Fabrizio
A1 Piras, Federica
A1 Plessen, Kerstin J
A1 Pomarol-Clotet, Edith
A1 Preda, Adrian
A1 Puig, Olga
A1 Quidé, Yann
A1 Radua, Joaquim
A1 Ramos-Quiroga, J Antoni
A1 Rasser, Paul E
A1 Rauer, Lisa
A1 Reddy, Janardhan
A1 Redlich, Ronny
A1 Reif, Andreas
A1 Reneman, Liesbeth
A1 Repple, Jonathan
A1 Retico, Alessandra
A1 Richarte, Vanesa
A1 Richter, Anja
A1 Rosa, Pedro G P
A1 Rubia, Katya K
A1 Hashimoto, Ryota
A1 Sacchet, Matthew D
A1 Salvador, Raymond
A1 Santonja, Javier
A1 Sarink, Kelvin
A1 Sarró, Salvador
A1 Satterthwaite, Theodore D
A1 Sawa, Akira
A1 Schall, Ulrich
A1 Schofield, Peter R
A1 Schrantee, Anouk
A1 Seitz, Jochen
A1 Serpa, Mauricio H
A1 Setién-Suero, Esther
A1 Shaw, Philip
A1 Shook, Devon
A1 Silk, Tim J
A1 Sim, Kang
A1 Simon, Schmitt
A1 Simpson, Helen Blair
A1 Singh, Aditya
A1 Skoch, Antonin
A1 Skokauskas, Norbert
A1 Soares, Jair C
A1 Soreni, Noam
A1 Soriano-Mas, Carles
A1 Spalletta, Gianfranco
A1 Spaniel, Filip
A1 Lawrie, Stephen M
A1 Stern, Emily R
A1 Stewart, S Evelyn
A1 Takayanagi, Yoichiro
A1 Temmingh, Henk S
A1 Tolin, David F
A1 Tomecek, David
A1 Tordesillas-Gutiérrez, Diana
A1 Tosetti, Michela
A1 Uhlmann, Anne
A1 van Amelsvoort, Therese
A1 van der Wee, Nic J A
A1 van der Werff, Steven J A
A1 van Haren, Neeltje E M
A1 van Wingen, Guido A
A1 Vance, Alasdair
A1 Vázquez-Bourgon, Javier
A1 Vecchio, Daniela
A1 Venkatasubramanian, Ganesan
A1 Vieta, Eduard
A1 Vilarroya, Oscar
A1 Vives-Gilabert, Yolanda
A1 Voineskos, Aristotle N
A1 Völzke, Henry
A1 von Polier, Georg G
A1 Walton, Esther
A1 Weickert, Thomas W
A1 Weickert, Cynthia Shannon
A1 Weideman, Andrea S
A1 Wittfeld, Katharina
A1 Wolf, Daniel H
A1 Wu, Mon-Ju
A1 Yang, T T
A1 Yang, Kun
A1 Yoncheva, Yuliya
A1 Yun, Je-Yeon
A1 Cheng, Yuqi
A1 Zanetti, Marcus V
A1 Ziegler, Georg C
A1 Franke, Barbara
A1 Hoogman, Martine
A1 Buitelaar, Jan K
A1 van Rooij, Daan
A1 Andreassen, Ole A
A1 Ching, Christopher R K
A1 Veltman, Dick J
A1 Schmaal, Lianne
A1 Stein, Dan J
A1 van den Heuvel, Odile A
A1 Turner, Jessica A
A1 van Erp, Theo G M
A1 Pausova, Zdenka
A1 Thompson, Paul M
A1 Paus, Tomáš
AB Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic resonance images. Similarity between interregional profiles of cell-specific gene expression and those in the group differences in cortical thickness were investigated in each disorder. Next, principal component analysis was used to reveal a shared profile of group difference in thickness across the disorders. Analysis for gene coexpression, clustering, and enrichment for genes associated with these disorders were conducted. Data analysis was conducted between June and December 2019. The analysis included 145 cohorts across 6 psychiatric disorders drawn from the ENIGMA consortium. The numbers of cases and controls in each of the 6 disorders were as follows: ADHD: 1814 and 1602; ASD: 1748 and 1770; BD: 1547 and 3405; MDD: 2658 and 3572; OCD: 2266 and 2007; and schizophrenia: 2688 and 3244. Interregional profiles of group difference in cortical thickness between cases and controls. A total of 12 721 cases and 15 600 controls, ranging from ages 2 to 89 years, were included in this study. Interregional profiles of group differences in cortical thickness for each of the 6 psychiatric disorders were associated with profiles of gene expression specific to pyramidal (CA1) cells, astrocytes (except for BD), and microglia (except for OCD); collectively, gene-expression profiles of the 3 cell types explain between 25% and 54% of variance in interregional profiles of group differences in cortical thickness. Principal component analysis revealed a shared profile of difference in cortical thickness across the 6 disorders (48% variance explained); interregional profile of this principal component 1 was associated with that of the pyramidal-cell gene expression (explaining 56% of interregional variation). Coexpression analyses of these genes revealed 2 clusters: (1) a prenatal cluster enriched with genes involved in neurodevelopmental (axon guidance) processes and (2) a postnatal cluster enriched with genes involved in synaptic activity and plasticity-related processes. These clusters were enriched with genes associated with all 6 psychiatric disorders. In this study, shared neurobiologic processes were associated with differences in cortical thickness across multiple psychiatric disorders. These processes implicate a common role of prenatal development and postnatal functioning of the cerebral cortex in these disorders.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/27200
UL https://hdl.handle.net/10668/27200
LA en
DS RISalud
RD Apr 4, 2025