RT Journal Article
T1 Smoking may increase the risk of hospitalization due to influenza
A1 Godoy, Pere
A1 Castilla, Jesus
A1 Maria Mayoral, Jose
A1 Delgado-Rodriguez, Miguel
A1 Martin, Vicente
A1 Astray, Jenaro
A1 Soldevila, Nuria
A1 Gonzalez-Candelas, Fernando
A1 Castro, Ady
A1 Baricot, Maretva
A1 Tamames, Sonia
A1 Alonso, Jordi
A1 Galan, Juan C.
A1 Maria Quintana, Jose
A1 Pumarola, Tomas
A1 Dominguez, Angela
A1 CIBERESP, 
K1 Community-acquired pneumonia
K1 Cigarette-smoking
K1 Population
K1 Infection
K1 Responses
K1 Exposure
K1 Disease
K1 Cells
AB Background: Smoking may facilitate influenza virus infections and their severity. The objective was to investigate the risk of hospitalization due to influenza in Spanish smokers and ex-smokers. Methods: We carried out a multicentre, case-control study in 2011. Cases [patients a parts per thousand yen 18 years hospitalized > 24 h with real time polymerase chain reaction (RT-PCR)-confirmed influenza] were selected from 29 Spanish hospitals. For each case, we selected an outpatient aged a parts per thousand yen 18 years with RT-PCR-confirmed influenza matched by age (+/- 5 years), date of hospitalization of the case (+/- 10 days) and province of residence. We collected epidemiological variables, comorbidities and the smoking history. The risk of hospitalization due to smoking was determined by the adjusted odds ratio (aOR) using logistic regression. Results: We studied 471 hospitalized cases and 476 outpatient cases. Hospitalized cases had a higher frequency of influenza risk factors compared with outpatient cases. Hospitalized cases had a higher frequency of smoking (30.9% vs. 17.1%) and being ex-smokers (29.3% vs. 25.3%). Current smoking (aOR = 2.18, 95% CI: 1.23-3.87) and being an ex-smoker (aOR = 1.73, 95% CI: 1.07-2.82) were associated with the risk of hospitalization. Conclusions: Smoking may increase the risk of hospitalization in smokers and ex-smokers when infected by the influenza virus. Smoking prevention could reduce hospitalizations. Influenza vaccination is recommended for smokers.
PB Oxford univ press
SN 1101-1262
YR 2016
FD 2016-10-01
LK http://hdl.handle.net/10668/18950
UL http://hdl.handle.net/10668/18950
LA en
DS RISalud
RD Apr 5, 2025