RT Journal Article
T1 Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia.
A1 Albasanz-Puig, Adaia
A1 Dura-Miralles, Xavier
A1 Laporte-Amargos, Julia
A1 Mussetti, Alberto
A1 Ruiz-Camps, Isabel
A1 Puerta-Alcalde, Pedro
A1 Abdala, Edson
A1 Oltolini, Chiara
A1 Akova, Murat
A1 Montejo, Jose Miguel
A1 Mikulska, Malgorzata
A1 Martin-Davila, Pilar
A1 Herrera, Fabian
A1 Gasch, Oriol
A1 Drgona, Lubos
A1 Paz-Morales, Hugo Manuel
A1 Brunel, Anne-Sophie
A1 Garcia, Estefanía
A1 Isler, Burcu
A1 Kern, Winfried V
A1 Retamar-Gentil, Pilar
A1 Aguado, Jose Maria
A1 Montero, Milagros
A1 Kanj, Souha S
A1 Sipahi, Oguz R
A1 Calik, Sebnem
A1 Marquez-Gomez, Ignacio
A1 Marin, Jorge I
A1 Gomes, Marisa Z R
A1 Hemmati, Philipp
A1 Araos, Rafael
A1 Peghin, Maddalena
A1 Del-Pozo, Jose Luis
A1 Yañez, Lucrecia
A1 Tilley, Robert
A1 Manzur, Adriana
A1 Novo, Andres
A1 Pallares, Natalia
A1 Bergas, Alba
A1 Carratala, Jordi
A1 Gudiol, Carlota
K1 Pseudomonas aeruginosa
K1 Bloodstream infection
K1 Neutropenia
K1 Pneumonia
K1 Septic shock
AB To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia. Among 1017 PA BSI episodes, pneumonia was the source of BSI in 294 (28.9%). Among those, 52 (17.7%) were caused by a multidrug-resistant (MDR) strain and 68 (23.1%) received IEAT, mainly when the infection was caused by an MDR strain [38/52 (73.1%) vs. 30/242 (12.4%); p< 0.001]. The 30-day case-fatality rate was higher in patients with PA bacteremic pneumonia than in those with PA BSI from other sources (55.1% vs. 31.4%; p < 0.001). IEAT was associated with increased 30-day case-fatality (aHR 1.44 [95%CI 1.01–2.03]; p = 0.042), whereas the use of appropriate combination empirical treatment was independentlyassociated with improved survival (aHR 0.46 [95%CI 0.27–0.78]; p = 0.004). Appropriate empirical monotherapy was not associated with improved overall survival (aHR 1.25 [95%CI 0.76–2.05]; p = 0.39). Combination antibiotic empirical therapy should be administered promptly in febrile neutropenic patients with suspected pneumonia as the source of infection
PB MDPI
SN 2076-2607
YR 2022
FD 2022-03-21
LK http://hdl.handle.net/10668/21434
UL http://hdl.handle.net/10668/21434
LA en
NO Albasanz-Puig A, Durà-Miralles X, Laporte-Amargós J, Mussetti A, Ruiz-Camps I, Puerta-Alcalde P, et al. Effect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pseudomonas aeruginosa Pneumonia. Microorganisms. 2022 Mar 29;10(4):733
DS RISalud
RD Apr 18, 2025