%0 Journal Article
%A Alvarado Sánchez, Jorge Iván
%A Caicedo Ruiz, Juan Daniel
%A Diaztagle Fernández, Juan Jose
%A Ospina Tascon, Gustavo Adolfo
%A Monge Garcia, Manuel Ignacio
%A Ruiz Narvaez, Guillermo Arturo
%A Cruz Martínez, Luis Eduardo
%T Changes of operative performance of pulse pressure variation as a predictor of fluid responsiveness in endotoxin shock.
%D 2022
%U http://hdl.handle.net/10668/19587
%X Several limitations regarding pulse pressure variation (PPV) use have been reported. Our aim was to describe changes in the PPV operative performance as a predictor of fluid responsiveness during the development of a swine endotoxin shock model and to assess hemodynamic variables associated with PPV changes. A swine porcine endotoxin shock model was established (Escherichia Coli 055:B5 endotoxin) in 7 pigs, and 3 pigs were included in the control group. The endotoxin was infused until the mean arterial pressure (MAP) dropped below 50 mmHg (TH0); then, the model animal was reanimated with fluids and vasopressors. We performed fluid challenges every hour for 6 h. ROC curve analysis and a linear mixed model were performed. The area under the curve of PPV decreased from 0.95 (0.81-1.00) to 0.60 (0.17-1.00) at TH0. Its cutoff increased from 10.5 to 22.00% at TH0. PPV showed an inverse relationship with stroke volume, mean systemic filling pressure, MAP, and systemic vascular resistance (SVR) (p 
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