RT Journal Article
T1 A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers.
A1 Marrero, Ana Dacil
A1 Castilla, Laura
A1 Espartero, Jose L
A1 Madrona, Andres
A1 Quesada, Ana R
A1 Medina, Miguel Angel
A1 Martinez-Poveda, Beatriz
K1 Angiogenesis
K1 Apoptosis
K1 Bovine aorta endothelial cells (BAEC)
K1 Chorioallantoic membrane (CAM) assay
K1 Hydroxytyrosyl alkyl ethers
AB The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenic potential of six synthetic hydroxytyrosyl alkyl ethers (HT C1, C2, C4, C6, C8 and C12). Our results showed that all compounds affected endothelial cell viability in vitro at low micromolar doses. In addition, compounds HT C1, C2, C4 and C6 inhibited endothelial cell migration and formation of tubular-like structures. In these assays, hydroxytyrosyl hexyl ether (HT C6) exhibited the most potent inhibitory activity in vitro, activating as well apoptosis in endothelial cells. Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in the chick chorioallantoic membrane assay. Hence, we present hydroxytyrosol synthetic derivative HT C6 as a new antiangiogenic compound and as a good candidate for an antiangiogenic drug in the treatment of angiogenesis-dependent diseases.
PB Elsevier BV
YR 2020
FD 2020-12-15
LK http://hdl.handle.net/10668/15963
UL http://hdl.handle.net/10668/15963
LA en
NO Marrero AD, Castilla L, Espartero JL, Madrona A, R Quesada A, Medina MÁ, et al. A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. Food Chem. 2020 Dec 15;333:127476.
DS RISalud
RD Nov 20, 2025