RT Journal Article
T1 A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers.
A1 Marrero, Ana Dácil
A1 Castilla, Laura
A1 Espartero, José L
A1 Madrona, Andrés
A1 R Quesada, Ana
A1 Medina, Miguel Ángel
A1 Martínez-Poveda, Beatriz
K1 Angiogenesis
K1 Apoptosis
K1 Bovine aorta endothelial cells (BAEC)
K1 Chorioallantoic membrane (CAM) assay
K1 Hydroxytyrosyl alkyl ethers
AB The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenic potential of six synthetic hydroxytyrosyl alkyl ethers (HT C1, C2, C4, C6, C8 and C12). Our results showed that all compounds affected endothelial cell viability in vitro at low micromolar doses. In addition, compounds HT C1, C2, C4 and C6 inhibited endothelial cell migration and formation of tubular-like structures. In these assays, hydroxytyrosyl hexyl ether (HT C6) exhibited the most potent inhibitory activity in vitro, activating as well apoptosis in endothelial cells. Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in the chick chorioallantoic membrane assay. Hence, we present hydroxytyrosol synthetic derivative HT C6 as a new antiangiogenic compound and as a good candidate for an antiangiogenic drug in the treatment of angiogenesis-dependent diseases.
YR 2020
FD 2020-07-05
LK http://hdl.handle.net/10668/15963
UL http://hdl.handle.net/10668/15963
LA en
DS RISalud
RD Mar 14, 2025