RT Journal Article
T1 Long-Term Results of Everolimus-Eluting Stents Versus Drug-Eluting Balloons in Patients With Bare-Metal In-Stent Restenosis: 3-Year Follow-Up of the RIBS V Clinical Trial.
A1 Alfonso, Fernando
A1 Pérez-Vizcayno, María José
A1 García Del Blanco, Bruno
A1 Otaegui, Imanol
A1 Masotti, Mónica
A1 Zueco, Javier
A1 Veláquez, Maite
A1 Sanchís, Juan
A1 García-Touchard, Arturo
A1 Lázaro-García, Rosa
A1 Moreu, José
A1 Bethencourt, Armando
A1 Cuesta, Javier
A1 Rivero, Fernando
A1 Cárdenas, Alberto
A1 Gonzalo, Nieves
A1 Jiménez-Quevedo, Pilar
A1 Fernández, Cristina
A1 RIBS V Study Investigators, 
K1 drug-eluting balloon(s)
K1 drug-eluting stent(s)
K1 everolimus-eluting stent(s)
K1 in-stent restenosis
AB The aim of this study was to compare the long-term efficacy of everolimus-eluting stents (EES) and drug-eluting balloons (DEB) in patients with bare-metal stent in-stent restenosis (ISR). The relative long-term clinical efficacy of current therapeutic modalities in patients with ISR remains unknown. The 3-year clinical follow-up (pre-specified endpoint) of patients included in the RIBS V (Restenosis Intra-Stent of Bare-Metal Stents: Drug-Eluting Balloon vs Everolimus-Eluting Stent Implantation) randomized clinical trial was analyzed. All patients were followed yearly using a pre-defined structured questionnaire. A total of 189 patients with bare-metal stent ISR were allocated to either EES (n = 94) or DEB (n = 95). Clinical follow-up at 1, 2, and 3 years was obtained in all patients (100%). Compared with patients treated with DEB, those treated with EES obtained better angiographic results, including larger minimal luminal diameter at follow-up (primary study endpoint; 2.36 ± 0.6 mm vs. 2.01 ± 0.6 mm; p 1 year) target vessel (3 [3.2%] vs. 3 [3.2%]; p = 0.95) and target lesion (1 [1%] vs. 2 [2.1%]; p = 0.54) revascularization was low and similar in the 2 arms. Rates of definite or probable stent thrombosis (1% vs. 0%) were also similar in the 2 arms. The 3-year clinical follow-up of the RIBS V clinical trial confirms the sustained safety and efficacy of EES and DEB in patients treated for bare-metal stent ISR. In this setting, EES reduce the need for target lesion revascularization at very long-term follow-up. (RIBS V [Restenosis Intra-Stent of Bare Metal Stents: Paclitaxel-Eluting Balloon vs Everolimus-Eluting Stent] [RIBS V]; NCT01239953).
YR 2016
FD 2016-06-20
LK http://hdl.handle.net/10668/10211
UL http://hdl.handle.net/10668/10211
LA en
DS RISalud
RD Apr 19, 2025