RT Journal Article
T1 Differences in life expectancy between men and women after aortic valve replacement.
A1 Hernandez-Vaquero, Daniel
A1 Rodriguez-Caulo, Emiliano
A1 Vigil-Escalera, Carlota
A1 Blanco-Herrera, Oscar
A1 Berastegui, Elisabet
A1 Arias-Dachary, Javier
A1 Souaf, Souhayla
A1 Parody, Gertrudis
A1 Laguna, Gregorio
A1 Adsuar, Alejandro
A1 Castellá, Manel
A1 Valderrama, José F
A1 Pulitani, Ivana
A1 Cánovas, Sergio
A1 Ferreiro, Andrea
A1 García-Valentín, Antonio
A1 Carnero, Manuel
A1 Pareja, Pilar
A1 Corrales, José A
A1 Blázquez, José A
A1 Macías, Diego
A1 Fletcher-Sanfeliu, Delfina
A1 Martínez, Daniel
A1 Martín, Elio
A1 Martín, Miren
A1 Margarit, Juan
A1 Hernández-Estefanía, Rafael
A1 Monguió, Emilio
A1 Otero, Juan
A1 Silva, Jacobo
K1 Aortic valve replacement
K1 Excess of mortality
K1 Severe aortic stenosis
AB Some researchers have observed an increased number of deaths during the follow-up of young patients who undergo aortic valve replacement due to severe aortic stenosis, suggesting that this procedure does not restore their life expectancy. Our goal was to confirm these findings and explore sex-based differences. All patients between 50 and 65 years of age who underwent isolated aortic valve replacement in 27 Spanish centres during an 18-year period were included. We compared observed and expected survival at 15 years of follow-up and estimated the cumulative incidence of death from a competing risks point of view. We stratified by sex and analysed if being a woman was an independent risk factor for death. For men, the observed survival at 10 and 15 years of follow-up was 85% [95% confidence interval (CI) 83.6%-86.4%] and 72.3% (95% CI 69.7%-74.7%), respectively whereas the expected survival was 88.1% and 78.8%. For women, the observed survival at 10 and 15 years was 85% (95% CI 82.8%-86.9%) and 73% (95% CI 69.1%-76.4%), whereas the expected survival was 94.6% and 89.4%. At 15 years of follow-up, the cumulative incidence of death due to the disease in men and women was 8.2% and 16.7%, respectively. In addition, being a woman was an independent risk factor for death (hazard ratio = 1.23 (95% CI 1.02-1.48; P = 0.03). After the aortic valve replacement, men and women do not have their life expectancy restored, but this loss is much higher in women than in men. In addition, being a woman is a risk factor for long-term death. Reasons for these findings are unknown and must be investigated.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/25280
UL https://hdl.handle.net/10668/25280
LA en
DS RISalud
RD Apr 17, 2025