TY  - JOUR
AU  - Artigas, Laura
AU  - Coma, Mireia
AU  - Matos-Filipe, Pedro
AU  - Aguirre-Plans, Joaquim
AU  - Farrés, Judith
AU  - Valls, Raquel
AU  - Fernandez-Fuentes, Narcis
AU  - de la Haba-Rodriguez, Juan
AU  - Olvera, Alex
AU  - Barbera, Jose
AU  - Morales, Rafael
AU  - Oliva, Baldo
AU  - Mas, Jose Manuel
PY  - 2020
DO  - 10.1371/journal.pone.0240149
UR  - http://hdl.handle.net/10668/3220
T2  - PLoS ONE
AB  - From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that in some cases can be complicated by the severe acute respiratory syndrome, sepsis and septic shock, multiorgan failure,...
LA  - en
PB  - PLOS
KW  - Coronavirus infections
KW  - Infecciones por coronavirus
KW  - Antiviral agents
KW  - Melatonin
KW  - Combined modality therapy
KW  - Antivirales
KW  - Melatonina
KW  - Terapia combinada
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiviral Agents
KW  - Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Melatonin
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Combined Modality Therapy
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Drug Discovery::Drug Repositioning
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines::Pyridones
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Proprotein Convertases::Furin
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Information Science::Information Science::Medical Informatics::Medical Informatics Applications::Information Systems::Databases as Topic::Databases, Factual::Databases, Pharmaceutical
TI  - In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm
TY  - research article
ER  -