%0 Journal Article
%A Quesada-Gomez, Jose Manuel
%A Entrenas-Castillo, Marta
%A Bouillon, Roger
%T Vitamin D receptor stimulation to reduce acute respiratory distress syndrome (ARDS) in patients with coronavirus SARS-CoV-2 infections: Revised Ms SBMB 2020_166.
%D 2020
%U http://hdl.handle.net/10668/15734
%X Coronavirus infection is a serious health problem awaiting an effective vaccine and/or antiviral treatment. The major complication of coronavirus disease 2019 (COVID-19), the Acute Respiratory Distress syndrome (ARDS), is due to a variety of mechanisms including cytokine storm, dysregulation of the renin-angiotensin system, neutrophil activation and increased (micro)coagulation. Based on many preclinical studies and observational data in humans, ARDS may be aggravated by vitamin D deficiency and tapered down by activation of the vitamin D receptor. Several randomized clinical trials using either oral vitamin D or oral Calcifediol (25OHD) are ongoing. Based on a pilot study, oral calcifediol may be the most promising approach. These studies are expected to provide guidelines within a few months.
%K 1α, 25(OH)2D or 1α, 25-dihydroxyvitamin D or calcitriol
%K Acute respiratory distress syndrome (ARDS)
%K Calcifediol or 25-hydroxyvitamin D3
%K Corona virus
%K Cytokine storm
%K Hypercoagulability
%K Lung diseases
%K Renin-angiotensin system
%K SARS-CoV-2
%K Vitamin D, vitamin D3 or cholecalciferol
%~