RT Journal Article
T1 GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke.
A1 Fernández-Cadenas, Israel
A1 Mendióroz, Maite
A1 Giralt, Dolors
A1 Nafria, Cristina
A1 Garcia, Elena
A1 Carrera, Caty
A1 Gallego-Fabrega, Cristina
A1 Domingues-Montanari, Sophie
A1 Delgado, Pilar
A1 Ribó, Marc
A1 Castellanos, Mar
A1 Martínez, Sergi
A1 Freijo, Marimar
A1 Jiménez-Conde, Jordi
A1 Rubiera, Marta
A1 Alvarez-Sabín, José
A1 Molina, Carlos A
A1 Font, Maria Angels
A1 Grau Olivares, Marta
A1 Palomeras, Ernest
A1 Perez de la Ossa, Natalia
A1 Martinez-Zabaleta, Maite
A1 Masjuan, Jaime
A1 Moniche, Francisco
A1 Canovas, David
A1 Piñana, Carlos
A1 Purroy, Francisco
A1 Cocho, Dolores
A1 Navas, Inma
A1 Tejero, Carlos
A1 Aymerich, Nuria
A1 Cullell, Natalia
A1 Muiño, Elena
A1 Serena, Joaquín
A1 Rubio, Francisco
A1 Davalos, Antoni
A1 Roquer, Jaume
A1 Arenillas, Juan Francisco
A1 Martí-Fábregas, Joan
A1 Keene, Keith
A1 Chen, Wei-Min
A1 Worrall, Bradford
A1 Sale, Michele
A1 Arboix, Adrià
A1 Krupinski, Jerzy
A1 Montaner, Joan
A1 GRECOS Study Group, 
K1 genetics
K1 ischemic attack, transient
K1 recurrence
K1 risk factors
K1 stroke
AB Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10-03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10-09) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
YR 2017
FD 2017-04-14
LK http://hdl.handle.net/10668/11095
UL http://hdl.handle.net/10668/11095
LA en
DS RISalud
RD Apr 8, 2025