%0 Journal Article
%A Fernández-Cadenas, Israel
%A Mendióroz, Maite
%A Giralt, Dolors
%A Nafria, Cristina
%A Garcia, Elena
%A Carrera, Caty
%A Gallego-Fabrega, Cristina
%A Domingues-Montanari, Sophie
%A Delgado, Pilar
%A Ribó, Marc
%A Castellanos, Mar
%A Martínez, Sergi
%A Freijo, Marimar
%A Jiménez-Conde, Jordi
%A Rubiera, Marta
%A Alvarez-Sabín, José
%A Molina, Carlos A
%A Font, Maria Angels
%A Grau Olivares, Marta
%A Palomeras, Ernest
%A Perez de la Ossa, Natalia
%A Martinez-Zabaleta, Maite
%A Masjuan, Jaime
%A Moniche, Francisco
%A Canovas, David
%A Piñana, Carlos
%A Purroy, Francisco
%A Cocho, Dolores
%A Navas, Inma
%A Tejero, Carlos
%A Aymerich, Nuria
%A Cullell, Natalia
%A Muiño, Elena
%A Serena, Joaquín
%A Rubio, Francisco
%A Davalos, Antoni
%A Roquer, Jaume
%A Arenillas, Juan Francisco
%A Martí-Fábregas, Joan
%A Keene, Keith
%A Chen, Wei-Min
%A Worrall, Bradford
%A Sale, Michele
%A Arboix, Adrià
%A Krupinski, Jerzy
%A Montaner, Joan
%A GRECOS Study Group
%T GRECOS Project (Genotyping Recurrence Risk of Stroke): The Use of Genetics to Predict the Vascular Recurrence After Stroke.
%D 2017
%U http://hdl.handle.net/10668/11095
%X Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack. Clinical scores do not predict the whole vascular recurrence risk; therefore, we aimed to find genetic variants associated with recurrence that might improve the clinical predictive models in IS. We analyzed 256 polymorphisms from 115 candidate genes in 3 patient cohorts comprising 4482 IS or transient ischemic attack patients. The discovery cohort was prospectively recruited and included 1494 patients, 6.2% of them developed a new IS during the first year of follow-up. Replication analysis was performed in 2988 patients using SNPlex or HumanOmni1-Quad technology. We generated a predictive model using Cox regression (GRECOS score [Genotyping Reurrence Risk of Stroke]) and generated risk groups using a classification tree method. The analyses revealed that rs1800801 in the MGP gene (hazard ratio, 1.33; P=9×10-03), a gene related to artery calcification, was associated with new IS during the first year of follow-up. This polymorphism was replicated in a Spanish cohort (n=1.305); however, it was not significantly associated in a North American cohort (n=1.683). The GRECOS score predicted new IS (P=3.2×10-09) and could classify patients, from low risk of stroke recurrence (1.9%) to high risk (12.6%). Moreover, the addition of genetic risk factors to the GRECOS score improves the prediction compared with previous Stroke Prognosis Instrument-II score (P=0.03). The use of genetics could be useful to estimate vascular recurrence risk after IS. Genetic variability in the MGP gene was associated with vascular recurrence in the Spanish population.
%K genetics
%K ischemic attack, transient
%K recurrence
%K risk factors
%K stroke
%~