RT Journal Article
T1 Influence of Gestational Diabetes and Pregestational Maternal BMI on the Brain of Six-Year-Old Offspring.
A1 Manuello, Jordi
A1 Verdejo-Roman, Juan
A1 Torres Espinola, Francisco
A1 Escudero-Marin, Mireia
A1 Catena, Andres
A1 Cauda, Franco
A1 Campoy, Cristina
K1 Body mass index
K1 Brain structure
K1 Gestational diabetes
K1 Transgenerational effects
AB Gestational diabetes (GD) and maternal excess weight are common pregnancy conditions that increase the risk of future complications for both the mother and her offspring. Their consequences on neurodevelopment are widely described in the literature, but less is known concerning the potential transgenerational influence on the brain structure. We used a combination of support vectors machine and hierarchical clustering to investigate the potential presence of anatomical brain differences in a sample of 109 children aged six years, born to mothers with overweight or obesity, or to mothers diagnosed with GD during pregnancy. Significant effects are visible in the brain of children born to mothers with GD associated with pregestational excess weight, especially overweight instead of obesity. No differences in children's brain were observed when considering those born to normal-weight mothers. Our study highlights the need for clinical attention of pregnant women at risk to develop GD, and especially those with pregestational excess weight, since this status was found to be associated with detectable transgenerational brain changes. These effects may be due to the absence of specific and individualized intervention in these mothers during pregnancy.
PB Elsevier Inc.
YR 2022
FD 2022-05-10
LK http://hdl.handle.net/10668/22469
UL http://hdl.handle.net/10668/22469
LA en
NO Manuello J, Verdejo-Román J, Torres Espínola F, Escudero-Marín M, Catena A, Cauda F, et al. Influence of Gestational Diabetes and Pregestational Maternal BMI on the Brain of Six-Year-Old Offspring. Pediatr Neurol. 2022 Aug;133:55-62.
DS RISalud
RD Apr 5, 2025