RT Journal Article
T1 Role of Mitochondria in Cancer Stem Cell Resistance
A1 García-Heredia, José Manuel
A1 Carnero, Amancio
K1 Cancer stem cells
K1 Mitochondria
K1 Drug resistance
K1 Metabolic plasticity
K1 Células madre neoplásicas
K1 Mitocondrias
K1 Resistencia a medicamentos
AB Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis. Various studies have shown that mitochondria play a central role in these processes because of the ability of this organelle to modify cell metabolism, allowing survival and avoiding apoptosis clearance of cancer cells. Thus, the whole mitochondrial cycle, from its biogenesis to its death, either by mitophagy or by apoptosis, can be targeted by different drugs to reduce mitochondrial fitness, allowing for a restored or increased sensitivity to chemotherapeutic drugs. Once mitochondrial misbalance is induced by a specific drug in any of the processes of mitochondrial metabolism, two elements are commonly boosted: an increment in reactive nitrogen/oxygen species and, subsequently, activation of the intrinsic apoptotic pathway.
PB MDPI
YR 2020
FD 2020-07-15
LK http://hdl.handle.net/10668/3619
UL http://hdl.handle.net/10668/3619
LA en
NO García-Heredia JM, Carnero A. Role of Mitochondria in Cancer Stem Cell Resistance. Cells. 2020 Jul 15;9(7):1693
DS RISalud
RD Apr 19, 2025