RT Journal Article
T1 Resensitization in suspected penicillin allergy.
A1 Doña, Inmaculada
A1 Guidolin, Lucia
A1 Bogas, Gádor
A1 Olivieri, Elisa
A1 Labella, Marina
A1 Schiappoli, Michele
A1 Sáenz de Santa María, Rocío
A1 Dama, Annarita
A1 Salas, María
A1 Senna, Gianenrico
A1 Bonadonna, Patrizia
A1 Torres, María José
K1 anaphylaxis
K1 drug provocation test
K1 penicillins
K1 resensitization
K1 skin test, specific IgE
AB The diagnosis of allergic reactions to penicillins (AR-PEN) is very complex as there is a loss of sensitization over time, which leads to negative skin tests (STs) and specific IgE in serum, and even to tolerance to the drug involved. However, STs may become positive after subsequent exposure to the culprit drug (resensitization), with the risk of inducing potentially severe reactions. The exact rate of resensitization to penicillins is unknown, ranging from 0% to 27.9% in published studies. To analyze the rate of resensitization in patients with suggestive AR-PEN by repeating STs (retest) after an initial evaluation (IE). Patients with suspected AR-PEN were prospectively evaluated between 2017 and 2020. They underwent STs, and a randomized group also underwent a drug provocation test (DPT) with the culprit. Only patients with negative STs and/or DPT were included. All included cases were retested by STs at 2-8 weeks. A total of 545 patients were included: 296 reporting immediate reactions (IRs) and 249 non-immediate reactions (NIRs). Eighty (14.7%) cases had positive results in retest (RT+): 63 (21.3%) IRs and 17 (6.8%) NIRs (p  Due to the high rate of resensitization, retest should be included in the diagnostic algorithm of IRs to penicillins after an initial negative study, especially in anaphylaxis, to avoid potentially severe reactions after subsequent prescriptions of these drugs.
YR 2022
FD 2022-09-15
LK http://hdl.handle.net/10668/19905
UL http://hdl.handle.net/10668/19905
LA en
DS RISalud
RD Apr 18, 2025