RT Journal Article
T1 Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
A1 Danese, Elisa
A1 Raimondi, Sara
A1 Montagnana, Martina
A1 Tagetti, Angela
A1 Langaee, Taimour
A1 Borgiani, Paola
A1 Ciccacci, Cinzia
A1 Carcas, Antonio J
A1 Borobia, Alberto M
A1 Tong, Hoi Y
A1 Dávila-Fajardo, Cristina
A1 Rodrigues Botton, Mariana
A1 Bourgeois, Stephane
A1 Deloukas, Panos
A1 Caldwell, Michael D
A1 Burmester, Jim K
A1 Berg, Richard L
A1 Cavallari, Larisa H
A1 Drozda, Katarzyna
A1 Huang, Min
A1 Zhao, Li-Zi
A1 Cen, Han-Jing
A1 Gonzalez-Conejero, Rocio
A1 Roldan, Vanessa
A1 Nakamura, Yusuke
A1 Mushiroda, Taisei
A1 Gong, Inna Y
A1 Kim, Richard B
A1 Hirai, Keita
A1 Itoh, Kunihiko
A1 Isaza, Carlos
A1 Beltrán, Leonardo
A1 Jiménez-Varo, Enrique
A1 Cañadas-Garre, Marisa
A1 Giontella, Alice
A1 Kringen, Marianne K
A1 Haug, Kari Bente Foss
A1 Gwak, Hye Sun
A1 Lee, Kyung Eun
A1 Minuz, Pietro
A1 Lee, Ming Ta Michael
A1 Lubitz, Steven A
A1 Scott, Stuart
A1 Mazzaccara, Cristina
A1 Sacchetti, Lucia
A1 Genç, Ece
A1 Özer, Mahmut
A1 Pathare, Anil
A1 Krishnamoorthy, Rajagopal
A1 Paldi, Andras
A1 Siguret, Virginie
A1 Loriot, Marie-Anne
A1 Kutala, Vijay Kumar
A1 Suarez-Kurtz, Guilherme
A1 Perini, Jamila
A1 Denny, Josh C
A1 Ramirez, Andrea H
A1 Mittal, Balraj
A1 Rathore, Saurabh Singh
A1 Sagreiya, Hersh
A1 Altman, Russ
A1 Shahin, Mohamed Hossam A
A1 Khalifa, Sherief I
A1 Limdi, Nita A
A1 Rivers, Charles
A1 Shendre, Aditi
A1 Dillon, Chrisly
A1 Suriapranata, Ivet M
A1 Zhou, Hong-Hao
A1 Tan, Sheng-Lan
A1 Tatarunas, Vacis
A1 Lesauskaite, Vaiva
A1 Zhang, Yumao
A1 Maitland-van der Zee, Anke H
A1 Verhoef, Talitha I
A1 de Boer, Anthonius
A1 Taljaard, Monica
A1 Zambon, Carlo Federico
A1 Pengo, Vittorio
A1 Zhang, Jieying Eunice
A1 Pirmohamed, Munir
A1 Johnson, Julie A
A1 Fava, Cristiano
AB The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7-10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.
YR 2019
FD 2019-02-17
LK http://hdl.handle.net/10668/13273
UL http://hdl.handle.net/10668/13273
LA en
DS RISalud
RD Mar 14, 2025