%0 Journal Article
%A Danese, Elisa
%A Raimondi, Sara
%A Montagnana, Martina
%A Tagetti, Angela
%A Langaee, Taimour
%A Borgiani, Paola
%A Ciccacci, Cinzia
%A Carcas, Antonio J
%A Borobia, Alberto M
%A Tong, Hoi Y
%A Dávila-Fajardo, Cristina
%A Rodrigues Botton, Mariana
%A Bourgeois, Stephane
%A Deloukas, Panos
%A Caldwell, Michael D
%A Burmester, Jim K
%A Berg, Richard L
%A Cavallari, Larisa H
%A Drozda, Katarzyna
%A Huang, Min
%A Zhao, Li-Zi
%A Cen, Han-Jing
%A Gonzalez-Conejero, Rocio
%A Roldan, Vanessa
%A Nakamura, Yusuke
%A Mushiroda, Taisei
%A Gong, Inna Y
%A Kim, Richard B
%A Hirai, Keita
%A Itoh, Kunihiko
%A Isaza, Carlos
%A Beltrán, Leonardo
%A Jiménez-Varo, Enrique
%A Cañadas-Garre, Marisa
%A Giontella, Alice
%A Kringen, Marianne K
%A Haug, Kari Bente Foss
%A Gwak, Hye Sun
%A Lee, Kyung Eun
%A Minuz, Pietro
%A Lee, Ming Ta Michael
%A Lubitz, Steven A
%A Scott, Stuart
%A Mazzaccara, Cristina
%A Sacchetti, Lucia
%A Genç, Ece
%A Özer, Mahmut
%A Pathare, Anil
%A Krishnamoorthy, Rajagopal
%A Paldi, Andras
%A Siguret, Virginie
%A Loriot, Marie-Anne
%A Kutala, Vijay Kumar
%A Suarez-Kurtz, Guilherme
%A Perini, Jamila
%A Denny, Josh C
%A Ramirez, Andrea H
%A Mittal, Balraj
%A Rathore, Saurabh Singh
%A Sagreiya, Hersh
%A Altman, Russ
%A Shahin, Mohamed Hossam A
%A Khalifa, Sherief I
%A Limdi, Nita A
%A Rivers, Charles
%A Shendre, Aditi
%A Dillon, Chrisly
%A Suriapranata, Ivet M
%A Zhou, Hong-Hao
%A Tan, Sheng-Lan
%A Tatarunas, Vacis
%A Lesauskaite, Vaiva
%A Zhang, Yumao
%A Maitland-van der Zee, Anke H
%A Verhoef, Talitha I
%A de Boer, Anthonius
%A Taljaard, Monica
%A Zambon, Carlo Federico
%A Pengo, Vittorio
%A Zhang, Jieying Eunice
%A Pirmohamed, Munir
%A Johnson, Julie A
%A Fava, Cristiano
%T Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.
%D 2019
%U http://hdl.handle.net/10668/13273
%X The cytochrome P450 (CYP)4F2 gene is known to influence mean coumarin dose. The aim of the present study was to undertake a meta-analysis at the individual patients level to capture the possible effect of ethnicity, gene-gene interaction, or other drugs on the association and to verify if inclusion of CYP4F2*3 variant into dosing algorithms improves the prediction of mean coumarin dose. We asked the authors of our previous meta-analysis (30 articles) and of 38 new articles retrieved by a systematic review to send us individual patients' data. The final collection consists of 15,754 patients split into a derivation and validation cohort. The CYP4F2*3 polymorphism was consistently associated with an increase in mean coumarin dose (+9% (95% confidence interval (CI) 7-10%), with a higher effect in women, in patients taking acenocoumarol, and in white patients. The inclusion of the CYP4F2*3 in dosing algorithms slightly improved the prediction of stable coumarin dose. New pharmacogenetic equations potentially useful for clinical practice were derived.
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