RT Journal Article
T1 Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas.
A1 Alhambra-Exposito, Maria R
A1 Ibañez-Costa, Alejandro
A1 Moreno-Moreno, Paloma
A1 Rivero-Cortes, Esther
A1 Vazquez-Borrego, Mari C
A1 Blanco-Acevedo, Cristobal
A1 Toledano-Delgado, Alvaro
A1 Lombardo-Galera, Maria S
A1 Vallejo-Casas, Juan A
A1 Gahete, Manuel D
A1 Castaño, Justo P
A1 Galvez, Maria A
A1 Luque, Raul M
K1 Acromegaly
K1 Biomarkers
K1 Disease management
K1 Disease susceptibility
K1 Growth hormone-secreting pituitary adenoma
AB Acromegaly is a rare but severe disease, originated in 95% of cases by a growth hormone-secreting adenoma (somatotropinoma) in the pituitary. Magnetic resonance imaging (MRI) is a non-invasive technique used for the diagnosis and prognosis of pituitary tumours. The aim of this study was to determine whether the use of T2-weighted signal intensity at MRI could help to improve the characterisation of somatotropinomas, by analysing its relationship with clinical/molecular features. An observational study was implemented in a cohort of 22 patients (mean age = 42.1 ± 17.2 years; 59% women; 95% size>10 mm). Suprasellar-extended somatotropinomas presented larger diameters vs. non-extended tumours. T2-imaging revealed that 59% of tumours were hyperintense and 41% isointense adenomas, wherein hyperintense were more invasive (according to Knosp-score) than isointense adenomas. A higher proportion of hyperintense somatotropinomas presented extrasellar-growth, suprasellar-growth and invasion of the cavernous sinus compared to isointense adenomas. Interestingly, somatostatin receptor-3 and dopamine receptor-5 (DRD5) expression levels were associated with extrasellar and/or suprasellar extension. Additionally, DRD5 was also higher in hyperintense adenomas and its expression was directly correlated with Knosp-score and with tumour diameter. Hence, T2-weighted MRI on somatotropinomas represents a potential tool to refine their diagnosis and prognosis, and could support the election of preoperative treatment, when required.
PB Nature Publishing Group
YR 2018
FD 2018-03-09
LK http://hdl.handle.net/10668/12367
UL http://hdl.handle.net/10668/12367
LA en
NO Alhambra-Expósito MR, Ibáñez-Costa A, Moreno-Moreno P, Rivero-Cortés E, Vázquez-Borrego MC, Blanco-Acevedo C, et al. Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas. Sci Rep. 2018 Apr 18;8(1):6173
NO Tis work has been funded by the following grants: Junta de Andalucía (CTS-1406, BIO-0139); Ministerio de Economía y Competitividad, Gobierno de España (BFU2013-43282, BFU2016-80360-R), Instituto de SaludCarlos III, co-funded by European Union (ERDF/ESF, “Investing in your future”; PI16/00264, CP15/00156), Ayuda Merck Serono 2013 and CIBERobn. CIBER is an initiative of Instituto de Salud Carlos III, Ministerio deSanidad, Servicios Sociales e Igualdad, Spain. Part of the analyses included in this study was carried out within the REMAH (‘Spanish molecular registry of pituitary adenomas’) project, supported by Novartis Oncology as well asby the Andalusian and Spanish Societies of Endocrinology and Nutrition (SAEDYN and SEEN).
DS RISalud
RD Apr 10, 2025