TY  - JOUR
AU  - Bettacchioli, Eléonore
AU  - Le Gaffric, Christelle
AU  - Mazeas, Margaux
AU  - Borghi, Maria Orietta
AU  - Frostegard, Johan
AU  - Barturen, Guillermo
AU  - Makowska, Zuzanna
AU  - Babei, Sepideh
AU  - Lesche, Ralf
AU  - PRECISESADS Clinical Consortium
AU  - Meroni, Pier Luigi
AU  - Alarcon-Riquelme, Marta E
AU  - Renaudineau, Yves
PY  - 2021
DO  - 10.1016/j.jtauto.2021.100090
UR  - https://hdl.handle.net/10668/28379
T2  - Journal of translational autoimmunity
AB  - High amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, SLE, SjS,...
LA  - en
KW  - APS, primary antiphospholipid syndrome
KW  - AUC, area under the curve
KW  - Ab, autoantibody
KW  - Autoantibodies
KW  - Autoimmune diseases
KW  - CCP, cyclic citrulinated peptide
KW  - CXCL10, C-X-C motif chemokine 10
KW  - F, female
KW  - FLC, free light chains
KW  - Free light chains
KW  - HC, healthy controls
KW  - IFN, interferon
KW  - Interferon signature
KW  - M, male
KW  - MCTD, mixed connective tissue disease
KW  - MDA, malondialdehyde
KW  - NK, natural killer
KW  - PC, phosphorylcholine
KW  - RA, rheumatoid arthritis
KW  - RF, rheumatoid factor
KW  - RNP, ribonucleoprotein
KW  - ROC, Receiver Operating Characteristics
KW  - SAD, systemic autoimmune diseases
KW  - SD, standard deviation
KW  - SLE, systemic lupus erythematosus
KW  - Scl, systemic sclerosis
KW  - SjS, Sjögren's syndrome
KW  - TH1, T helper type 1
KW  - TNF-R1, tumor necrosis factor receptor 1
KW  - UCTD, undetermined connective tissue disease
KW  - VAS, visual analogical scale
KW  - κ, kappa
KW  - λ, lambda
TI  - An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases.
TY  - research article
VL  - 4
ER  -