RT Journal Article
T1 Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
A1 Ramírez-López, María Teresa
A1 Arco, Raquel
A1 Decara, Juan
A1 Vázquez, Mariam
A1 Blanco, Rosario Noemí
A1 Alén, Francisco
A1 Suárez, Juan
A1 Gómez de Heras, Raquel
A1 Rodríguez de Fonseca, Fernando
K1 Tejido adiposo
K1 Adiposidad
K1 Niños Adultos
K1 Animales
K1 Cannabinoides
K1 Dieta
K1 Endocannabinoides
K1 Metabolismo Energético
K1 Conducta alimentaria
K1 Femenino
K1 Hipercolesterolemia
K1 Hipertrigliceridemia
K1 Hipotálamo
K1 Lactancia
K1 Hígado
K1 Masculino
K1 Metaboloma
K1 Obesidad
K1 Embarazo
K1 ARN mensajero
K1 Receptor cannabinoide CB2
K1 Destete
AB Recent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of endocannabinoid-related behaviors, b) the metabolic profile of adult offspring and c) the mRNA expression of the signaling machinery of the ECS in the hypothalamus, the liver and the adipose tissue of adult offspring of both sexes. Exposure to a palatable diet resulted in a) sex-dimorphic and perinatal diet specific feeding behaviors, including the differential response to the inhibitory effects of the cannabinoid receptor inverse agonist AM251, b) features of metabolic syndrome including increased adiposity, hyperleptinemia, hypertriglyceridemia and hypercholesterolemia and c) tissue and sex-specific changes in the expression of both CB1 and CB2 receptors and in that of the endocannabinoid-degrading enzymes FAAH and MAGL, being the adipose tissue the most affected organ analyzed. Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.
PB Public Libray of Science
YR 2016
FD 2016-11-02
LK http://hdl.handle.net/10668/2542
UL http://hdl.handle.net/10668/2542
LA en
NO Ramírez-López MT, Arco R, Decara J, Vázquez M, Blanco RN, Alén F, et al. Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring. PLoS ONE. 2016; 11(11):e0165432
NO Journal Article;
DS RISalud
RD Apr 5, 2025