RT Journal Article
T1 Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients.
A1 Ramos-Vivas, José
A1 Chapartegui-González, Itziar
A1 Fernández-Martínez, Marta
A1 González-Rico, Claudia
A1 Fortún, Jesús
A1 Escudero, Rosa
A1 Marco, Francesc
A1 Linares, Laura
A1 Montejo, Miguel
A1 Aranzamendi, Maitane
A1 Muñoz, Patricia
A1 Valerio, Maricela
A1 Aguado, Jose María
A1 Resino, Elena
A1 Ahufinger, Irene Gracia
A1 Vega, Aurora Paz
A1 Martínez-Martínez, Luis
A1 Fariñas, María Carmen
A1 ENTHERE Study Group, the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbiology (GESITRA-SEIMC) and the Spanish Network for Research in Infectious Diseases (REIPI)
AB Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (Escherichia coli n = 106, Klebsiella pneumoniae n = 78, and Enterobacter spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of E. coli strains, 73% of K. pneumoniae strains and 4% Enterobacter strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4 K. pneumoniae, 1 E. coli and 1 Enterobacter spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that in vitro biofilm formation could be an important factor for adhesion to intestine and colonization in MDR K. pneumoniae strains in SOT recipients, but this factor appears to be less important for MDR E. coli and Enterobacter spp.
YR 2019
FD 2019-06-20
LK http://hdl.handle.net/10668/14153
UL http://hdl.handle.net/10668/14153
LA en
DS RISalud
RD Apr 7, 2025