TY - JOUR AU - Dieguez-Gonzalez, Rebeca AU - Calaza, Manuel AU - Perez-Pampin, Eva AU - Balsa, Alejandro AU - Blanco, Francisco J AU - Cañete, Juan D AU - Cáliz, Rafael AU - Carreño, Luís AU - Serna, Arturo R de la AU - Fernandez-Gutierrez, Benjamín AU - Ortiz, Ana Maria AU - Herrero-Beaumont, Gabriel AU - Pablos, Jose L AU - Narvaez, Javier AU - Navarro, Federico AU - Marenco, Jose L AU - Gomez-Reino, Juan J AU - Gonzalez, Antonio PY - 2009 DO - 10.1186/ar2650 SN - 1478-6354 UR - http://hdl.handle.net/10668/601 T2 - Arthritis research & therapy AB - INTRODUCTIONGenome-wide association studies of rheumatoid arthritis (RA) have identified an association of the disease with a 6q23 region devoid of genes. TNFAIP3, an RA candidate gene, flanks this region, and polymorphisms in both the TNFAIP3 gene... LA - en PB - BioMed Central KW - Intracellular Signaling Peptides and Proteins KW - NF-kappa B KW - Nuclear Proteins KW - TNFAIP3 protein, human KW - Humanos KW - Péptidos y Proteínas de Señalización Intracelular KW - Realizador del VIH KW - Proteínas Nucleares KW - Reacción en Cadena de la Polimerasa KW - Polimorfismo de Nucleótido Simple KW - DNA, Intergenic KW - Cromosomas Humanos Par 6 KW - ADN Intergénico KW - Predisposición Genética a la Enfermedad KW - Estudio de Asociación del Genoma Completo KW - Péptidos y Proteínas de Señalización Intracelular KW - Artritis Reumatoide KW - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 6-12 and X::Chromosomes, Human, Pair 6 KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Intergenic KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Study KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::NF-kappa B KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide KW - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid TI - Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-κB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility TY - research article ER -