RT Journal Article T1 SEOM Clinical Guideline for gastrointestinal sarcomas (GIST) (2016) A1 Poveda, A. A1 Martinez, V. A1 Serrano, C. A1 Sevilla, I. A1 Lecumberri, M. J. A1 de Beveridge, R. D. A1 Estival, A. A1 Vicente, D. A1 Rubio, J. A1 Martin-Broto, J. K1 GIST K1 Imatinib K1 Sunitinib K1 Regorafenib K1 Stromal tumors K1 Adjuvant imatinib K1 Randomized-trial K1 Phase-iii K1 Follow-up K1 Kinase K1 Risk K1 Multicenter K1 Sensitivity K1 Recurrence AB Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract, and this disease has served as a paradigmatic model for successful rational development of targeted therapies. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly deemed resistant to all systemic therapies. The Spanish Society of Medical Oncology (SEOM) guidelines provide a multidisciplinary and updated consensus for the diagnosis and treatment of GIST patients. We strongly encourage that the managing of these patients should be performed within multidisciplinary teams in reference centers. PB Springer-verlag italia srl SN 1699-048X YR 2016 FD 2016-12-01 LK http://hdl.handle.net/10668/18651 UL http://hdl.handle.net/10668/18651 LA en DS RISalud RD Apr 8, 2025