RT Journal Article
T1 Sexual Regional Dimorphism of Post-Adolescent and Middle Age Brain Maturation. A Multi-center 3T MRI Study.
A1 Delvecchio, Giuseppe
A1 Maggioni, Eleonora
A1 Pigoni, Alessandro
A1 Crespo-Facorro, B
A1 Nenadić, Igor
A1 Benedetti, Francesco
A1 Gaser, Christian
A1 Sauer, Heinrich
A1 Roiz-Santiañez, Roberto
A1 Poletti, Sara
A1 Rossetti, Maria G
A1 Bellani, Marcella
A1 Perlini, Cinzia
A1 Ruggeri, Mirella
A1 Diwadkar, Vaibhav A
A1 Brambilla, Paolo
K1 aging
K1 healthy individuals
K1 magnetic resonance imaging
K1 sex differences
K1 sexual dimorphism
AB Sex-related differences are tied into neurodevelopmental and lifespan processes, beginning early in the perinatal and developmental phases and continue into adulthood. The present study was designed to investigate sexual dimorphism of changes in gray matter (GM) volume in post-adolescence, with a focus on early and middle-adulthood using a structural magnetic resonance imaging (MRI) dataset of healthy controls from the European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT). Three hundred and seventy three subjects underwent a 3.0 T MRI session across four European Centers. Age by sex effects on GM volumes were investigated using voxel-based morphometry (VBM) and the Automated Anatomical Labeling atlas regions (ROI). Females and males showed overlapping and non-overlapping patterns of GM volume changes during aging. Overlapping age-related changes emerged in bilateral frontal and temporal cortices, insula and thalamus. Both VBM and ROI analyses revealed non-overlapping changes in multiple regions, including cerebellum and vermis, bilateral mid frontal, mid occipital cortices, left inferior temporal and precentral gyri. These findings highlight the importance of accounting for sex differences in cross-sectional analyses, not only in the study of normative changes, but particularly in the context of psychiatric and neurologic disorders, wherein sex effects may be confounded with disease-related changes.
SN 1663-4365
YR 2021
FD 2021-02-05
LK https://hdl.handle.net/10668/27376
UL https://hdl.handle.net/10668/27376
LA en
DS RISalud
RD Apr 12, 2025