RT Journal Article T1 Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering A1 Santisteban-Espejo, Antonio A1 Martin-Piedra, Miguel Angel A1 Campos, Antonio A1 Moran-Sanchez, Julia A1 Cobo, Manuel J. A1 Pacheco-Serrano, Ana I. A1 Moral-Munoz, Jose A. K1 Advanced therapies K1 Tissue engineering K1 Scientometrics K1 Altmetrics K1 Online K1 Web K1 Communication of science K1 Terapéutica K1 Ingeniería tisular K1 Sistemas en línea K1 Navegador web K1 Comunicación en salud K1 Bibliometría K1 Medios de comunicación de masas AB Background: Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-stage organs. Its development has taken place since the last decade of the 20th century, entailing a clinical revolution. TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact. Objective: The objective of this study was to evaluate the online dimension of TE documents from 2012 to 2018 using metadata obtained from the Web of Science (WoS) and Altmetric and to develop a prediction equation for the impact of TE documents from altmetric scores.Methods: We analyzed 10,112 TE documents through descriptive and statistical methods. First, the TE temporal evolution was exposed for WoS and 15 online platforms (news, blogs, policy, Twitter, patents, peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, video, and Mendeley Readers). The 10 most cited TE original articles were ranked according to the normalized WoS citations and the normalized Altmetric Attention Score. Second, to better comprehend the TE online framework, correlation and factor analyses were performed based on the suitable results previously obtained for the Bartlett sphericity and Kaiser–Meyer–Olkin tests. Finally, the linear regression model was applied to elucidate the relation between academics and online media and to construct a prediction equation for TE from altmetrics data. Results: TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers, and Altmetric Scores. However, WoS and Altmetric rankings for the most cited documents clearly differ. When compared, the best correlation results were obtained for Mendeley Readers and WoS (ρ=0.71). In addition, the factor analysis identified 6 factors that could explain the previously observed differences between academic institutions and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than 40% of TE WoS citations from Altmetric scores.Conclusions: Scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because the focus of TE research importantly differs when the academic institutions and online platforms PB JMIR Publications SN 1439-4456 YR 2021 FD 2021-11-26 LK http://hdl.handle.net/10668/3939 UL http://hdl.handle.net/10668/3939 LA en NO Santisteban-Espejo A, Martin-Piedra MA, Campos A, Moran-Sanchez J, Cobo MJ, Pacheco-Serrano AI, et al. Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering. J Med Internet Res. 2021 Nov 26;23(11):e25394 DS RISalud RD Apr 5, 2025