RT Journal Article
T1 Determinants of maximal oxygen uptake in patients with heart failure.
A1 Roibal Pravio, Javier
A1 Barge Caballero, Eduardo
A1 Barbeito Caamaño, Cayetana
A1 Paniagua Martin, Maria Jesus
A1 Barge Caballero, Gonzalo
A1 Couto Mallon, David
A1 Pardo Martinez, Patricia
A1 Grille Cancela, Zulaika
A1 Blanco Canosa, Paula
A1 García Pinilla, Jose Manuel
A1 Vázquez Rodríguez, Jose Manuel
A1 Crespo Leiro, Maria Generosa
K1 Cardiopulmonary exercise testing
K1 Heart failure
K1 Maximum oxygen uptake
K1 Prognostic value
AB Maximum oxygen uptake (VO2max ) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not been well characterized yet. We conducted a retrospective, observational, single-centre study of 362 consecutive patients with HF who underwent cardiopulmonary exercise testing (CPET) as part of standard clinical assessment since 2009-2019. CPET was performed on treadmill, according to Bruce's protocol (n = 360) or Naughton's protocol (n = 2). We performed multivariable linear regression analyses in order to identify independent clinical predictors associated with peak VO2max . Mean age of study patients was 57.3 ± 10.9 years, mean left ventricular ejection fraction was 32.8 ± 14.2%, and mean VO2max was 19.8 ± 5.2 mL/kg/min. Eighty-nine (24.6%) patients were women, and 114 (31.5%) had ischaemic heart disease. Multivariable linear regression analysis identified six independent clinical predictors of VO2max , including NYHA class (B coefficient = -2.585; P  The severity of HF (NYHA class, NT-proBNP) as well as age, body composition and haemoglobin levels influence significantly exercise capacity. In patients with HF, the right ventricular systolic function is of greater importance for the physical capacity than the left ventricular systolic function.
YR 2021
FD 2021-03-27
LK http://hdl.handle.net/10668/17411
UL http://hdl.handle.net/10668/17411
LA en
DS RISalud
RD Apr 11, 2025