TY - JOUR AU - Ortega, Francisco G AU - Roefs, Marieke T AU - de Miguel Perez, Diego AU - Kooijmans, Sander A AU - de Jong, Olivier G AU - Sluijter, Joost P AU - Schiffelers, Raymond M AU - Vader, Pieter PY - 2019 DO - 10.1016/j.nano.2019.102014 UR - http://hdl.handle.net/10668/14053 T2 - Nanomedicine : nanotechnology, biology, and medicine AB - Exosomes are cell-derived extracellular vesicles of 30-150 nm in size and are involved in intercellular communication. Because of their bioactive cargo, consisting of proteins, RNA and lipids, and their natural ability to deliver these biomolecules to... LA - en KW - Endolysosomal trafficking KW - Exosome functionality KW - Exosomes KW - Extracellular vesicles KW - Regenerative medicine KW - Vesicle biogenesis KW - Ammonium Chloride KW - Biological Transport KW - Biomarkers KW - Cell Cycle Proteins KW - Cell Line, Tumor KW - Chloroquine KW - Endosomes KW - Endothelial Cells KW - Exosomes KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Lysosomes KW - MAP Kinase Signaling System KW - Myocardium KW - Neovascularization, Physiologic KW - Phosphorylation KW - Proto-Oncogene Proteins c-akt KW - Stem Cells TI - Interfering with endolysosomal trafficking enhances release of bioactive exosomes. TY - research article VL - 20 ER -