RT Journal Article
T1 An Olive-Derived Extract 20% Rich in Hydroxytyrosol Prevents β-Amyloid Aggregation and Oxidative Stress, Two Features of Alzheimer Disease, via SKN-1/NRF2 and HSP-16.2 in Caenorhabditis elegans.
A1 Romero-Márquez, Jose M
A1 Navarro-Hortal, María D
A1 Jiménez-Trigo, Victoria
A1 Muñoz-Ollero, Pedro
A1 Forbes-Hernández, Tamara Y
A1 Esteban-Muñoz, Adelaida
A1 Giampieri, Francesca
A1 Delgado Noya, Irene
A1 Bullón, Pedro
A1 Vera-Ramírez, Laura
A1 Battino, Maurizio
A1 Sánchez-González, Cristina
A1 Quiles, José L
K1 HSP-16.2
K1 Olea europaea
K1 RNAi
K1 age-related diseases
K1 antioxidants
K1 neuroprotection
K1 olive by-products
K1 polyphenols
K1 tau protein
AB Olive milling produces olive oil and different by-products, all of them very rich in different bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim of the present study was to investigate the effects of an olive fruit extract 20% rich in hydroxytyrosol on the molecular mechanisms associated with Alzheimer disease features like Aβ- and tau- induced toxicity, as well as on oxidative stress in Caenorhabditis elegans. Moreover, characterization of the extracts, regarding the profile and content of phenolics, as well as total antioxidant ability, was investigated. The study of lethality, growth, pharyngeal pumping, and longevity in vivo demonstrated the lack of toxicity of the extract. One hundred μg/mL of extract treatment revealed prevention of oxidative stress and a delay in Aβ-induced paralysis related with a lower presence of Aβ aggregates. Indeed, the extract showed the ability to avoid a certain degree of proteotoxicity associated with aggregation of the tau protein. According to RNAi tests, SKN-1/NRF2 transcription factor and the overexpression of HSP-16.2 were mechanistically associated in the observed effects.
SN 2076-3921
YR 2022
FD 2022-03-25
LK http://hdl.handle.net/10668/20778
UL http://hdl.handle.net/10668/20778
LA en
DS RISalud
RD Apr 8, 2025