RT Journal Article T1 Editorial: Mechanisms and New Targets for the Treatment of Chronic Pain. A1 Nieto, Francisco Rafael A1 Vuckovic, Sonja Maksim A1 Prostran, Milica S K1 analgesics K1 cancer-related pain K1 chronic pain K1 musculoskeletal pain K1 neuropathic pain K1 pain K1 persistent pain K1 visceral pain AB Nociceptive pain has a physiological protective role in preventing tissue injury. However, pain can become chronic due to a multitude of pathophysiological states, such as: inflammation, nerve injury, tumors, infections, autoimmune diseases, and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to painful hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes chronic, pathologic, and it can be extremely debilitating for people who suffer from it (Basbaum et al., 2009). Chronic pain has recently been defined as pain that persists or recurs for more than 3 months (Treede et al., 2019) PB Frontiers Research Foundation SN 1663-9812 YR 2020 FD 2020-09-16 LK http://hdl.handle.net/10668/16497 UL http://hdl.handle.net/10668/16497 LA en NO Nieto FR, Vuckovic SM, Prostran MS. Editorial: Mechanisms and New Targets for the Treatment of Chronic Pain. Front Pharmacol. 2020 Sep 29;11:600037. doi: 10.3389/fphar.2020.600037. DS RISalud RD Apr 16, 2025