%0 Journal Article
%A Peg, Vicente
%A López-García, María Ángeles
%A Comerma, Laura
%A Peiró, Gloria
%A García-Caballero, Tomás
%A López, Ángel Concha
%A Suárez-Gauthier, Ana
%A Ruiz, Irune
%A Rojo, Federico
%T PD-L1 testing based on the SP142 antibody in metastatic triple-negative breast cancer: summary of an expert round-table discussion.
%D 2020
%U http://hdl.handle.net/10668/16754
%X Triple-negative breast cancer (TNBC) is more aggressive than other breast cancer subtypes. TNBC is characterized by increased expression of Programmed Death-ligand 1 (PD-L1), a signal used by many tumors to escape the immune response. Expression of PD-L1 is a positive predictor of response to immunotherapy; therefore, it should be investigated in TNBC in order to select patients who may benefit from anti-PD-L1 therapies. While many PD-L1 assays are available, only the VENTANA platform with the anti-PD-L1 (SP142) antibody is licensed as a companion diagnostic device for selecting patients with metastatic/advanced TNBC who are candidates for treatment with atezolizumab. In this article, we provide a summary of an expert round-table discussion about PD-L1 testing, using the SP142 antibody in metastatic TNBC.
%K PD-L1
%K antibody
%K breast cancer
%K diagnosis
%K immunohistochemistry
%K immunotherapy
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