RT Journal Article
T1 Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age.
A1 Olalla, Julian
A1 Garcia de Lomas, Jose M
A1 Chueca, Natalia
A1 Perez-Stachowski, Xavier
A1 De Salazar, Adolfo
A1 Del Arco, Alfonso
A1 Plaza-Diaz, Julio
A1 De la Torre, Javier
A1 Prada, Jose Luis
A1 Garcia-Alegria, Javier
A1 Fernandez-Sanchez, Fernando
A1 Garcia, Federico
K1 Cholesterol
K1 aging
K1 extra virgin olive oil
K1 HIV
K1 microbiota
AB Extra virgin olive oil (EVOO) has shown beneficial effects on the lipid profile and inflammatory parameters in general population. Our goal is to analyze these changes together with those of intestinal microbiota in human immunodeficiency virus (HIV)-infected patients over 50 years of age. Experimental single arm open study. HIV patients over the age of 50 with undetectable viral load were selected. EVOO was distributed among the patients so that each one consumed 50 g daily for 12 weeks. Lipid profile, C-reactive protein (CRP), and intestinal microbiota composition were analyzed at the beginning and at the end of the intervention. Total cholesterol decreased significantly (5 mg/dL), and a nonsignificant decrease in low-density lipoprotein cholesterol (12 mg/dL), triglycerides (21 mg/dL), and CRP (1.25 mg/dL) was observed. There was a significant increase in alpha diversity after the intervention in men and a decrease in proinflammatory genera such as Dethiosulfovibrionaceae was observed. Differences were also observed in the microbiota of men and women and according to the type of antiretroviral treatment. Sustained consumption of 50 g of EVOO in elderly HIV-infected patients might be associated with an improvement in lipid profile and alfa diversity of intestinal microbiota.
PB Wolters Kluwer Health
YR 2019
FD 2019-09-16
LK http://hdl.handle.net/10668/14945
UL http://hdl.handle.net/10668/14945
LA en
NO Olalla J, García de Lomas JM, Chueca N, Pérez-Stachowski X, De Salazar A, Del Arco A, et al. Effect of daily consumption of extra virgin olive oil on the lipid profile and microbiota of HIV-infected patients over 50 years of age. Medicine (Baltimore). 2019 Oct;98(42):e17528.
NO The authors thank the patients who collaborated in thedevelopment of this project and to the olive company BravolivaS.L., who selflessly donated the extra virgin olive oil necessary forthe project. The authors thank the Grants from Plan Nacional deI+D+I and Fondo Europeo de Desarrollo Regional-FEDER(RD16/0025/0040; http://www.isciii.es/isciii/es/contenidos/fdinvestigacion/fd-ejecucion/fd-centros-participados/centros-participados-redesretics.shtml) and Fondo de Investigación Sanitaria(PI 18/00819) for the financial support. And the authors alsothank Josefa López-Bueno for assistance in the analysis of themicrobiota by next generation sequencing.
DS RISalud
RD Apr 12, 2025