RT Journal Article T1 Frequent Consumption of Sugar- and Artificially Sweetened Beverages and Natural and Bottled Fruit Juices Is Associated with an Increased Risk of Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Disease Risk. A1 Ferreira-Pêgo, Cíntia A1 Babio, Nancy A1 Bes-Rastrollo, Maira A1 Corella, Dolores A1 Estruch, Ramon A1 Ros, Emilio A1 Fitó, Montserrat A1 Serra-Majem, Lluís A1 Arós, Fernando A1 Fiol, Miguel A1 Santos-Lozano, José Manuel A1 Muñoz-Bravo, Carlos A1 Pintó, Xavier A1 Ruiz-Canela, Miguel A1 Salas-Salvadó, Jordi A1 PREDIMED Investigators, K1 PREDIMED study K1 artificially sweetened beverages K1 fruit juices K1 metabolic syndrome K1 metabolic syndrome components K1 sugar-sweetened beverages AB The relation between the consumption of sweetened beverages and metabolic syndrome (MetS) is controversial. This analysis evaluated the associations between intakes of sugar-sweetened beverages (SSBs), artificially sweetened beverages, and natural and bottled fruit juices and the incidence of MetS in elderly individuals at high risk of cardiovascular disease (CVD) and without MetS at baseline. We prospectively examined 1868 participants free of MetS at baseline from the PREDIMED (PREvención con DIeta MEDiterránea) study. MetS was defined by using the updated harmonized criteria of the International Diabetes Federation, the American Heart Association, and National Heart, Lung, and Blood Institute. Energy and nutrient intakes were evaluated at baseline and then yearly by using a validated 137-item food-frequency questionnaire. Multivariable-adjusted HRs for MetS and its components were estimated from mean intakes during follow-up. We compared the 2 highest consumption categories (1-5 and >5 servings/wk) with the lowest category (5 servings/wk) with the lowest category ( A total of 930 incident cases of MetS were documented during a median follow-up of 3.24 y. When we compared consumption of >5 servings/wk with consumption of 5 servings/wk with consumption of The occasional consumption of SSBs and artificially sweetened beverages (1-5 servings/wk) was not associated with the incidence of MetS in middle-aged and elderly individuals at high risk of CVD. The consumption of >5 servings/wk of all of the types of beverages analyzed was associated with an increased risk of MetS and some of its components. However, for SSBs and bottled fruit juices these associations must be interpreted with caution because of the low frequency of consumption in this population. This trial was registered at clinicaltrials.gov as ISRCTN35739639. YR 2016 FD 2016-06-29 LK http://hdl.handle.net/10668/10225 UL http://hdl.handle.net/10668/10225 LA en DS RISalud RD Apr 9, 2025