RT Journal Article
T1 MEN1-associated primary hyperparathyroidism in the Spanish Registry: clinical characterictics and surgical outcomes.
A1 Lamas, Cristina
A1 Navarro, Elena
A1 Casterás, Anna
A1 Portillo, Paloma
A1 Alcázar, Victoria
A1 Calatayud, María
A1 Álvarez-Escolá, Cristina
A1 Sastre, Julia
A1 Boix, Evangelina
A1 Forga, Lluis
A1 Vicente, Almudena
A1 Oriola, Josep
A1 Mesa, Jordi
A1 Valdés, Nuria
K1 MEN1 gene
K1 hypoparathyroidism
K1 multiple endocrine neoplasia type 1
K1 parathyroidectomy
K1 primary hyperparathyroidism
AB Primary hyperparathyroidism is the most frequent manifestation of multiple endocrine neoplasia type 1 (MEN1) syndrome. Bone and renal complications are common. Surgery is the treatment of choice, but the best timing for surgery is controversial and predictors of persistence and recurrence are not well known. Our study describes the clinical characteristics and the surgical outcomes, after surgery and in the long term, of the patients with MEN1 and primary hyperparathyroidism included in the Spanish Registry of Multiple Endocrine Neoplasia, Pheochromocytomas and Paragangliomas (REGMEN). Eighty-nine patients (49 men and 40 women, 34.2 ± 13 years old) were included. Sixty-four out of the 89 underwent surgery: a total parathyroidectomy was done in 13 patients, a subtotal parathyroidectomy in 34 and a less than subtotal parathyroidectomy in 15. Remission rates were higher after a total or a subtotal parathyroidectomy than after a less than subtotal (3/4 and 20/22 vs 7/12, P
SN 2049-3614
YR 2019
FD 2019
LK https://hdl.handle.net/10668/27427
UL https://hdl.handle.net/10668/27427
LA en
DS RISalud
RD Apr 6, 2025