RT Journal Article T1 Impact of an intermittent and localized cooling intervention on skin temperature, sleep quality and energy expenditure in free-living, young, healthy adults. A1 Xu, Huiwen A1 Martinez-Nicolas, Antonio A1 Martinez-Avila, Wendy D A1 Alcantara, Juan M A A1 Corral-Perez, Juan A1 Jimenez-Pavon, David A1 Acosta, Francisco M A1 Ruiz, Jonatan R A1 Martinez-Tellez, Borja K1 Cold exposure K1 Outdoor ambient temperature K1 Thermoregulation K1 Wrist skin temperature K1 iButton AB Where people live and work together it is not always possible to modify the ambient temperature; ways must therefore be found that allow individuals to feel thermally comfortable in such settings. The Embr Wave® is a wrist-worn device marketed as a 'personal thermostat' that can apply a local cooling stimulus to the skin. The aim of the present study was to determine the effect of an intermittent mild cold stimulus of 25 °C for 15-20 s every 5 min over 3.5 days under free-living conditions on 1) skin temperature, 2) perception of skin temperature, 3) sleep quality and 4) resting energy expenditure (REE) in young, healthy adults. Ten subjects wore the device for 3.5 consecutive days. This intervention reduced distal skin temperature after correcting for personal ambient temperature (P < 0.05), but did not affect the subjects’ the perception of skin temperature, sleep quality or REE (all P ≥ 0.051). Thus, this intermittent mild cold regime can reduce distal skin temperature, and wearing it under free-living conditions for 3.5 days does not seem to impair the perception of skin temperature and sleep quality or modify REE. PB Elsevier SN 0306-4565 YR 2021 FD 2021-02-10 LK http://hdl.handle.net/10668/17591 UL http://hdl.handle.net/10668/17591 LA en NO Xu H, Martinez-Nicolas A, Martinez-Avila WD, Alcantara JMA, Corral-Perez J, Jimenez-Pavon D, et al. Impact of an intermittent and localized cooling intervention on skin temperature, sleep quality and energy expenditure in free-living, young, healthy adults. J Therm Biol. 2021 Apr;97:102875 NO The study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigacion ´ Sanitaria del Instituto de Salud Carlos III (PI13/01393 and CB16/10/00239) and PTA 12264-I, Retos de la Sociedad (DEP2016-79512-R), and European Regional Development Funds (ERDF). Other funders included the Spanish Min istry of Education (FPU 16/05159 , 15/04059 and 19/02326), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas De Investigación Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca HealthCare Foundation, the University of Granada Plan Propio de Investigacion ´ 2016 (Excellence actions: Unit of Excellence on Exercise, Nutrition and Health [UCEENS]), and by the Junta de Anda lucía, Consejería de Conocimiento, Investigacion ´ y Universidades (ERDF, SOMM17/6107/UGR). AMT was supported by S´eneca Founda tion through grant 19899/GERM/15 and the Ministry of Science Inno vation and Universities RTI2018-093528-B-I0, as well as DJP (MINECO; RYC-2014-16938). BMT was supported by an individual postdoctoral grant from the Fundacion ´ Alfonso Martin Escudero. We thank Dr. Matt Smith of Embr Labs Inc. for configuring the Embr Wave® devices used in this experiment. DS RISalud RD Apr 7, 2025