RT Journal Article T1 Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial. A1 Schröder, Helmut A1 Cardenas-Fuentes, Gabriela A1 Martinez-Gonzalez, Miguel Angel A1 Corella, Dolores A1 Vioque, Jesus A1 Romaguera, Dora A1 Alfredo Martínez, J A1 Tinahones, Francisco J A1 Miranda, Jose Lopez A1 Estruch, Ramon A1 Bueno-Cavanillas, Aurora A1 Aros, Fernando A1 Marcos, Ascension A1 Tur, Josep A A1 Warnberg, Julia A1 Serra-Majem, Lluis A1 Martin, Vicente A1 Vazquez, Clotilde A1 Lapetra, Jose A1 Pinto, Xavier A1 Vidal, Josep A1 Daimiel, Lidia A1 Gaforio, Jose Juan A1 Matia-Martin, Pilar A1 Ros, Emilio A1 Castañer, Olga A1 Lassale, Camille A1 Ruiz-Canela, Miguel A1 Asensio, Eva M A1 Basora, Josep A1 Torres-Collado, Laura A1 Garcia-Rios, Antonio A1 Abete, Itziar A1 Toledo, Estefania A1 Buil-Cosiales, Pilar A1 Bullo, Monica A1 Goday, Albert A1 Fito, Montserrat A1 Salas-Salvado, Jordi K1 Body mass index K1 Intervention program K1 Older adults K1 Physical activity K1 Randomized control trial K1 Waist circumference AB The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component. PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups. After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7-136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p  After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults. PB BioMed Central YR 2018 FD 2018-10-25 LK http://hdl.handle.net/10668/13181 UL http://hdl.handle.net/10668/13181 LA en NO Schröder H, Cárdenas-Fuentes G, Martínez-González MA, Corella D, Vioque J, Romaguera D, et al. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial. Int J Behav Nutr Phys Act. 2018 Nov 13;15(1):110 DS RISalud RD Apr 7, 2025