RT Journal Article T1 Respiratory symptoms and their determinants in the general Spanish population: changes over 20 years A1 Miravitlles, Marc A1 Jose Soler-Cataluna, Juan A1 Soriano, Joan B. A1 Garcia-Rio, Francisco A1 De Lucas, Pilar A1 Alfageme, Inmaculada A1 Casanova, Ciro A1 Rodriguez Gonzalez-Moro, Jose Miguel A1 Sanchez, Guadalupe A1 Ancochea, Julio A1 Cosio, Borja G. K1 Physical-activity survey K1 Copd K1 Validation K1 Questionnaire K1 Community K1 Mortality K1 Dyspnea K1 Adults K1 Scale AB Background Few large epidemiological studies have analysed the prevalence of respiratory symptoms and their determinants in the general adult population. We investigated the prevalence and determinants of respiratory symptoms and compared their prevalence with that of two previous studies conducted in 1999 and 2009.Method EPISCAN II was a multicentre, cross-sectional, population-based epidemiological study in individuals older than 40 years.Results A total of 9092 individuals were included. Up to 47.5% reported at least one respiratory symptom, being more frequent in women than in men (49.4% versus 45.5%, p=0.0002) and with wheezing being the most frequent (33.7%) followed by dyspnoea (26.8%). The presence of any symptom was associated with female sex, higher body mass index (BMI), lower forced expiratory volume in 1 s (FEV1 % pred), reduced physical activity, a higher Charlson index and the presence of anxiety and depression. Smoking was also significantly associated with having at least one respiratory symptom in a dose-response fashion (OR: 1.415, 1.916, 2.192 and 2.987 for 0-10, 10-20, 20-30 and >30 pack-years, respectively, all p30 pack-years, respectively, all p PB European respiratory soc journals ltd YR 2022 FD 2022-10-01 LK http://hdl.handle.net/10668/20256 UL http://hdl.handle.net/10668/20256 LA en DS RISalud RD Apr 7, 2025