RT Journal Article
T1 Late pulmonary metastases of renal cell carcinoma immediatelyafter post-transplantation immunosuppressive treatment: a case report
A1 Cozar, Jose M
A1 Aptsiauri, Natalia
A1 Tallada, Miguel
A1 Garrido, Federico
A1 Ruiz-Cabello, Francisco
K1 Carcinoma de Células Renales
K1 Metástasis de la Neoplasia
K1 Inmunosupresores
K1 Trasplante de Riñón
K1 Nefrectomía
K1 Nephrectomy
AB INTRODUCTIONWe report a case of pulmonary metastatic recurrence of renal adenocarcinoma soon after radical nephrectomy that was followed by renal transplant and immunosuppressive medication. Increased risk of metastatic recurrence of renal cell carcinoma should be considered in the immediate post-transplant period when immunosuppressive medication is administered, even if nephrectomy had been performed many years earlier.CASE PRESENTATIONIn 1986 the patient demonstrated renal insufficiency secondary to mesangial glomerulonephritis. In 1992 he underwent left side radical nephrectomy with histopathological diagnosis of clear cell adenocarcinoma. Mesangial glomerulonephritis in the remaining right kidney progressed to end-stage renal failure. In October 2000 he received a kidney transplant from a cadaver and commenced immunosuppressive medication. Two months later, several nodules were found in his lungs, which were identified as metastases from the primary renal tumor that had been removed with the diseased kidney 8 years earlier.CONCLUSIONRecurrence of renal cell carcinoma metastases points to tumor dormancy and reflects a misbalance between effective tumor immune surveillance and immune escape. This case demonstrates that a state of tumor dormancy can be interrupted soon after administration of immunosuppressant medication.
PB BioMed Central
YR 2008
FD 2008-04-18
LK http://hdl.handle.net/10668/639
UL http://hdl.handle.net/10668/639
LA en
NO Cózar JM, Aptsiauri N, Tallada M, Garrido F, Ruiz-Cabello F. Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report. J Med Case Rep. 2008 Apr 18;2:111.
NO Journal Article;
DS RISalud
RD Apr 7, 2025