RT Journal Article
T1 Molecular epidemiology of paediatric invasive pneumococcal disease in Andalusia, Spain.
A1 de-Felipe, Beatriz
A1 Obando-Pacheco, Pablo
A1 Carazo-Gallego, Begoña
A1 Lopez-Martin, David
A1 Santos-Perez, Juan Luis
A1 Gonzalez-Jimenez, Yolanda
A1 Muñoz-Vilches, Maria Jose
A1 Cardelo-Autero, Nerea
A1 Gonzalez-Galan, Veronica
A1 Moron, Francisco Jose
A1 Cordero-Varela, Juan Antonio
A1 Torres-Sanchez, Maria Jose
A1 Medina-Claros, Antonio
A1 Moreno-Perez, David
A1 Obando, Ignacio
K1 Genotypes
K1 Streptococcus pneumoniae
K1 Invasive pneumococcal disease
K1 Pneumococcal conjugate vaccine
K1 Serotypes
K1 Área de Gestión Sanitaria Sur de Sevilla
AB This study aimed to assess the impact of the introduction of pneumococcal conjugate vaccine 13 (PCV13) on the molecular epidemiology of invasive pneumococcal disease (IPD) in children from Andalusia. A population-based prospective surveillance study was conducted on IPD in children aged <14 years from Andalusia (2018–2020). Pneumococcal invasive isolates collected between 2006 and 2009 in the two largest tertiary hospitals in Andalusia were used as pre-PCV13 controls for comparison of serotype/genotype distribution. Overall IPD incidence rate was 3.55 cases per 100000 in 2018; increased non-significantly to 4.20 cases per 100000 in 2019 and declined in 2020 to 1.69 cases per 100000 (incidence rate ratio 2020 vs. 2019: 0.40, 95% confidence interval (CI) 0.20–0.89, P = 0.01). Proportion of IPD cases due to PCV13 serotypes in 2018–2020 was 28% (P=0.0001 for comparison with 2006–2009). Serotypes 24F (15%) and 11A (8.3%) were the most frequently identified nonPCV13 serotypes (NVT) in 2018–2020. Penicillin- and/or ampicillin-resistant clones mostly belonged to clonal complex 156 (serotype 14-ST156 and ST2944 and serotype 11AST6521). The proportion of IPD cases caused by PCV13 serotypes declined significantly after the initiation of the PCV13 vaccination programme in 2016. Certain NVT, such as serotypes 24F and 11A, warrant future monitoring in IPD owing to invasive potential and/or antibiotic resistance rates.
PB Cambridge University Press
YR 2022
FD 2022-08-22
LK http://hdl.handle.net/10668/22580
UL http://hdl.handle.net/10668/22580
LA en
NO de Felipe B, Obando Pacheco P, Carazo Gallego B, López Martín D, Santos Pérez JL, González Jiménez Y, et al. Molecular epidemiology of paediatric invasive pneumococcal disease in Andalusia, Spain. Epidemiol Infect. 2022 Aug 22;150:e163
DS RISalud
RD May 10, 2025