RT Generic
T1 Mitochondrial control of cell bioenergetics in Parkinson's disease
A1 Requejo-Aguilar, Raquel
A1 Bolanos, Juan P.
K1 Parkinson's disease
K1 Mitochondria
K1 Lysosome
K1 Autophagy
K1 Glycolysis
K1 Pentose-phosphate pathway
AB Parkinson disease (PD) is a neurodegenerative disorder characterized by a selective loss of dopaminergic neurons in the substantia nigra. The earliest biochemical signs of the disease involve failure in mitochondrial-endoplasmic reticulum cross talk and lysosomal function, mitochondrial electron chain impairment, mitochondrial dynamics alterations, and calcium and iron homeostasis abnormalities. These changes are associated with increased mitochondrial reactive oxygen species (mROS) and energy deficiency. Recently, it has been reported that, as an attempt to compensate for the mitochondrial dysfunction, neurons invoke glycolysis as a low-efficient mode of energy production in models of PD. Here, we review how mitochondria orchestrate the maintenance of cellular energetic status in PD, with special focus on the switch from oxidative phosphorylation to glycolysis, as well as the implication of endoplasmic reticulum and lysosomes in the control of bioenergetics. 
PB Elsevier
SN 0891-5849
YR 2016
FD 2016-04-14
LK http://hdl.handle.net/10668/18779
UL http://hdl.handle.net/10668/18779
LA en
NO Requejo-Aguilar R, Bolaños JP. Mitochondrial control of cell bioenergetics in Parkinson's disease. Free Radic Biol Med. 2016 Nov;100:123-137
NO 3237-1), the ISCIII (RD12/0043/0021), the EU SP3-People-MC-ITNprogram (608381), the EU BATCure grant (666918), the NIH/NIDA(1R21DA037678-01).
DS RISalud
RD Apr 12, 2025