RT Journal Article
T1 Angiogenic Imbalance and Inflammatory Biomarkers in the Prediction of Hypertension as Well as Obstetric and Perinatal Complications in Women with Gestational Diabetes Mellitus.
A1 Lara-Barea, Almudena
A1 Sanchez-Lechuga, Begoña
A1 Campos-Caro, Antonio
A1 Cordoba-Doña, Juan Antonio
A1 de la Varga-Martinez, Raquel
A1 Arroba, Ana I
A1 Bugatto, Fernando
A1 Aguilar-Diosdado, Manuel
A1 Lopez-Tinoco, Cristina
K1 Angiogenic factors
K1 Gestational diabetes
K1 Hypertensive disorders of pregnancy
K1 sFlt-1/PIGF ratio
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
AB Gestational diabetes mellitus (GDM) increases the risk of hypertensive disorders of pregnancy (HDP). We aimed to analyze the altered inflammatory markers and angiogenic factors among women with GDM to identify pregnant women at higher risk of developing HDP. Methods: This was a prospective study of 149 women without hypertension diagnosed in the third trimester with GDM. Inflammatory markers and angiogenic factors were measured at 28−32 weeks of pregnancy. Obstetric and perinatal outcomes were evaluated. Results: More than eight percent of the women developed HDP. Higher levels of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) ratio (4.9 ± 2.6 versus 2.3 ± 1.3, respectively; p< 0.001) and leptin (10.9 ± 0.8 versus 10.08 ± 1.1, respectively; p = 0.038), as well as lower levels of adiponectin (10.5 ± 1.3 versus 12.9 ± 2.7, respectively; p = 0.031), were seen in women who developed HDP versus normotensive women with GDM. A multivariable logistic regression analysis showed that adiponectin had a protective effect with 0.45-fold odds (0.23–0.83; p = 0.012), and that the sFlt-1/PIGF ratio was associated with 2.70-foldodds of developing HDP (CI 95%: 1.24–5.86; p = 0.012). Conclusion: An increase in angiogenic imbalance in the sFlt-1/PIGF ratio in women with GDM was detected and may be an indicator of developing HDP in addition to any subsequent obstetric and perinatal complications.
PB MDPI
SN 2077-0383
YR 2022
FD 2022-03-08
LK http://hdl.handle.net/10668/21254
UL http://hdl.handle.net/10668/21254
LA en
NO Lara-Barea A, Sánchez-Lechuga B, Campos-Caro A, Córdoba-Doña JA, de la Varga-Martínez R, Arroba AI, et al. Angiogenic Imbalance and Inflammatory Biomarkers in the Prediction of Hypertension as Well as Obstetric and Perinatal Complications in Women with Gestational Diabetes Mellitus. J Clin Med. 2022 Mar 10;11(6):1514
DS RISalud
RD Apr 6, 2025