RT Journal Article
T1 The diagnosis and management of allergic reactions in patients sensitized to non-specific lipid transfer proteins.
A1 Skypala, Isabel J
A1 Bartra, Joan
A1 Ebo, Didier G
A1 Antje Faber, Margaretha
A1 Fernández-Rivas, Montserrat
A1 Gomez, Francisca
A1 Luengo, Olga
A1 Till, Stephen J
A1 Asero, Riccardo
A1 Barber, Domingo
A1 Cecchi, Lorenzo
A1 Diaz Perales, Araceli
A1 Hoffmann-Sommergruber, Karin
A1 Anna Pastorello, Elide
A1 Swoboda, Ines
A1 Konstantinopoulos, Anastasios P
A1 van Ree, Ronald
A1 Scala, Enrico
A1 European Academy of Allergy & Clinical Immunology (EAACI) Task Force: Non-specific Lipid Transfer Protein Allergy Across Europe, 
K1 cofactors
K1 diagnosis
K1 lipid transfer protein
K1 management
AB Sensitization to one or more non-specific lipid transfer proteins (nsLTPs), initially thought to exist mainly in southern Europe, is becoming accepted as a cause of allergic reactions to plant foods across Europe and beyond. The peach nsLTP allergen Pru p 3 is a dominant sensitizing allergen and peaches a common food trigger, although multiple foods can be involved. A frequent feature of reactions is the requirement for a cofactor (exercise, alcohol, non-steroidal anti-inflammatory drugs, Cannabis sativa) to be present for a food to elicit a reaction. The variability in the food and cofactor triggers makes it essential to include an allergy-focused diet and clinical history in the diagnostic workup. Testing on suspected food triggers should also establish whether sensitization to nsLTP is present, using purified or recombinant nsLTP allergens such as Pru p 3. The avoidance of known trigger foods and advice on cofactors is currently the main management for this condition. Studies on immunotherapy are promising, but it is unknown whether such treatments will be useful in populations where Pru p 3 is not the primary sensitizing allergen. Future research should focus on the mechanisms of cofactors, improving diagnostic accuracy and establishing the efficacy of immunotherapy.
YR 2021
FD 2021-03-27
LK http://hdl.handle.net/10668/17263
UL http://hdl.handle.net/10668/17263
LA en
DS RISalud
RD Apr 11, 2025