RT Journal Article
T1 Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke.
A1 Tsivgoulis, Georgios
A1 Saqqur, Maher
A1 Sharma, Vijay K
A1 Brunser, Alejandro
A1 Eggers, Jürgen
A1 Mikulik, Robert
A1 Katsanos, Aristeidis H
A1 Sergentanis, Theodore N
A1 Vadikolias, Konstantinos
A1 Perren, Fabienne
A1 Rubiera, Marta
A1 Bavarsad Shahripour, Reza
A1 Nguyen, Huy Thang
A1 Martínez-Sánchez, Patricia
A1 Safouris, Apostolos
A1 Heliopoulos, Ioannis
A1 Shuaib, Ashfaq
A1 Derksen, Carol
A1 Voumvourakis, Konstantinos
A1 Psaltopoulou, Theodora
A1 Alexandrov, Anne W
A1 Alexandrov, Andrei V
A1 CLOTBUST-PRO investigators, 
K1 Outcomes
K1 Reperfusion
K1 Stroke
K1 Thrombolysis
AB Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FFO) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0-1 and 0-2 respectively. We enrolled 480 AIS patients (mean age 66±15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53%) had significantly (P Earlier tPA treatment after stroke onset is associated with faster tPA-induced recanalization. Earlier onset-to-recanalization time. in improved functional recovery and survival in AIS patients with proximal intracranial occlusions.
SN 2287-6391
YR 2020
FD 2020-01-31
LK http://hdl.handle.net/10668/15059
UL http://hdl.handle.net/10668/15059
LA en
DS RISalud
RD Apr 18, 2025