%0 Journal Article
%A Tsivgoulis, Georgios
%A Saqqur, Maher
%A Sharma, Vijay K
%A Brunser, Alejandro
%A Eggers, Jürgen
%A Mikulik, Robert
%A Katsanos, Aristeidis H
%A Sergentanis, Theodore N
%A Vadikolias, Konstantinos
%A Perren, Fabienne
%A Rubiera, Marta
%A Bavarsad Shahripour, Reza
%A Nguyen, Huy Thang
%A Martínez-Sánchez, Patricia
%A Safouris, Apostolos
%A Heliopoulos, Ioannis
%A Shuaib, Ashfaq
%A Derksen, Carol
%A Voumvourakis, Konstantinos
%A Psaltopoulou, Theodora
%A Alexandrov, Anne W
%A Alexandrov, Andrei V
%A CLOTBUST-PRO investigators
%T Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke.
%D 2020
%@ 2287-6391
%U http://hdl.handle.net/10668/15059
%X Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FFO) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0-1 and 0-2 respectively. We enrolled 480 AIS patients (mean age 66±15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53%) had significantly (P Earlier tPA treatment after stroke onset is associated with faster tPA-induced recanalization. Earlier onset-to-recanalization time. in improved functional recovery and survival in AIS patients with proximal intracranial occlusions.
%K Outcomes
%K Reperfusion
%K Stroke
%K Thrombolysis
%~