RT Journal Article
T1 Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha.
A1 Conde, Isabel
A1 Lobo, María V T
A1 Zamora, Javier
A1 Pérez, Julio
A1 González Sánchez, Francisco Jesús
A1 Alba Conejo, Emilio
A1 Fraile, Benito
A1 Paniagua, Ricardo
A1 Arenas, María I
K1 pregnane X receptor
K1 Western Blotting
K1 Anciano
K1 Neoplasia de la mama
K1 Carcinoma ductal de mama
K1 Dimerización
K1 Supervivencia sin Enfermedad
K1 Inmunohistoquímica
K1 Estadificación de Neoplasias
K1 Receptores de Esteroides
K1 Receptor alfa X Retinoide
K1 Receptores x Retinoide
K1 Adulto
K1 Mediana edad
K1 Humanos
K1 Femenino
K1 Carcinoma in situ
K1 Anciano de 80 o más Años
AB BACKGROUNDThe human pregnane X receptor (hPXR) is an orphan nuclear receptor that induces transcription of response elements present in steroid-inducible cytochrome P-450 gene promoters. This activation requires the participation of retinoid X receptors (RXRs), needed partners of hPXR to form heterodimers. We have investigated the expression of hPXR and RXRs in normal, premalignant, and malignant breast tissues, in order to determine whether their expression profile in localized infiltrative breast cancer is associated with an increased risk of recurrent disease.METHODSBreast samples from 99 patients including benign breast diseases, in situ and infiltrative carcinomas were processed for immunohistochemistry and Western-blot analysis.RESULTSCancer cells from patients that developed recurrent disease showed a high cytoplasmic location of both hPXR isoforms. Only the infiltrative carcinomas that relapsed before 48 months showed nuclear location of hPXR isoform 2. This location was associated with the nuclear immunoexpression of RXR-alpha.CONCLUSIONBreast cancer cells can express both variants 1 and 2 of hPXR. Infiltrative carcinomas that recurred showed a nuclear location of both hPXR and RXR-alpha; therefore, the overexpression and the subcellular location changes of hPXR could be considered as a potential new prognostic indicator.
PB BioMed Central
YR 2008
FD 2008-06-19
LK http://hdl.handle.net/10668/820
UL http://hdl.handle.net/10668/820
LA en
NO Conde I, Lobo MV, Zamora J, Pérez J, González Sánchez FJ, Alba Conejo E, et al. Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha. BMC Cancer; 8:174
NO Journal Article;
DS RISalud
RD Apr 7, 2025