RT Journal Article
T1 Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
A1 Marazuela, Paula
A1 Bonaterra-Pastra, Anna
A1 Faura, Júlia
A1 Penalba, Anna
A1 Pizarro, Jesús
A1 Pancorbo, Olalla
A1 Rodríguez-Luna, David
A1 Vert, Carla
A1 Rovira, Alex
A1 Pujadas, Francesc
A1 Freijo, M. Mar
A1 Tur, Silvia
A1 Martínez-Zabaleta, Maite
A1 Cardona Portela, Pere
A1 Vera, Rocío
A1 Lebrato-Hernández, Lucia
A1 Arenillas, Juan F.
A1 Pérez-Sánchez, Soledad
A1 Montaner, Joan
A1 Delgado, Pilar
A1 Hernández-Guillamon, Mar
K1 Aquaporin 4
K1 Cerebral amyloid angiopathy
K1 Intracerebral hemorrhage
K1 Magnetic resonance imaging markers
K1 Functional outcome
K1 Enzyme-linked immunosorbent assay
K1 Acuaporina 4
K1 Angiopatía amiloide cerebral
K1 Hemorragia cerebral
K1 Imagen por resonancia magnética
K1 Ensayo de inmunoadsorción enzimática
AB Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
PB MDPI
YR 2021
FD 2021-03-02
LK http://hdl.handle.net/10668/4571
UL http://hdl.handle.net/10668/4571
LA en
NO Marazuela P, Bonaterra-Pastra A, Faura J, Penalba A, Pizarro J, Pancorbo O, et al. Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage. J Clin Med. 2021 Mar 2;10(5):989
DS RISalud
RD Feb 14, 2025