%0 Journal Article
%A Marazuela, Paula
%A Bonaterra-Pastra, Anna
%A Faura, Júlia
%A Penalba, Anna
%A Pizarro, Jesús
%A Pancorbo, Olalla
%A Rodríguez-Luna, David
%A Vert, Carla
%A Rovira, Alex
%A Pujadas, Francesc
%A Freijo, M. Mar
%A Tur, Silvia
%A Martínez-Zabaleta, Maite
%A Cardona Portela, Pere
%A Vera, Rocío
%A Lebrato-Hernández, Lucia
%A Arenillas, Juan F.
%A Pérez-Sánchez, Soledad
%A Montaner, Joan
%A Delgado, Pilar
%A Hernández-Guillamon, Mar
%T Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
%D 2021
%U http://hdl.handle.net/10668/4571
%X Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
%K Aquaporin 4
%K Cerebral amyloid angiopathy
%K Intracerebral hemorrhage
%K Magnetic resonance imaging markers
%K Functional outcome
%K Enzyme-linked immunosorbent assay
%~